Comparison of the Intracarotid Amobarbital Procedure and Interictal Cerebral 18‐Fluorodeoxyglucose Positron Emission Tomography Scans in Refractory Temporal Lobe Epilepsy

V. Salanova, H. H. Morris, P. Rehm, E. Wyllie, D. S. Dinner, H. Lüders, W. Gilmore‐Pollak

Research output: Contribution to journalArticle

27 Scopus citations


Summary: The relationship between interictal focal hypometabolism determined by 18‐fluorodeoxyglucose positron emission tomography (FDG‐PET) scans and memory function with the intracarotid amobarbital procedure (IAP) was evaluated in 23 patients with temporal lobe epilepsy. All patients underwent prolonged EEG/video monitoring. The epileptogenic focus was defined by interictal epileptiform discharges and ictal onsets. All 23 patients had recorded seizures arising exclusively from one temporal lobe. PET showed temporal lobe hypometabolism ipsilateral to the epileptogenic focus in 86% (20 of 23) of patients; IAP showed impaired memory of the hemisphere of seizure onset in 65% (15 of 23). Sixty‐five percent (13 of 20) of patients with focal hypometabolism had ipsilateral memory impairment. Memory impairment contralateral to the hypometabolic zone was not observed. Ninety‐five percent (22 of 23) of patients demonstrated functional impairment by either PET or IAP (or both) on the epileptogenic side.

Original languageEnglish (US)
Pages (from-to)635-638
Number of pages4
Issue number4
StatePublished - Jul 1992



  • Complex partial seizures
  • Epilepsy
  • Intracarotid amobarbital test
  • Neurosurgery
  • Positron emission tomography scan
  • Temporal lobe

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

Cite this