Comparison of Usefulness of Body Mass Index Versus Metabolic Risk Factors in Predicting 10-Year Risk of Cardiovascular Events in Women

Yiqing Song, Jo Ann E. Manson, James B. Meigs, Paul M. Ridker, Julie E. Buring, Simin Liu

Research output: Contribution to journalArticle

85 Scopus citations

Abstract

The objective of this study was to prospectively examine the comparative importance of body mass index (BMI) and metabolic syndrome (MS) related risk factors in predicting future risk of cardiovascular disease (CVD) in women. Of 25,626 women aged ≥45 years and free of CVD, cancer, and diabetes at baseline in the Women's Health Study, all women were classified into 6 groups according to 3 BMI categories (<25, 25 to 29.9, and ≥30 kg/m2) and the presence or absence of MS, defined using modified criteria of the National Cholesterol Education Program Adult Treatment Program III. During a median 10-year follow-up, 724 incident CVD events were documented. Compared with lean women without MS, multivariate relative risks of CVD, adjusting for age, physical activity, and other covariates, were 2.40 (95% confidence interval [CI] 1.71 to 3.37) for lean women who had MS, 1.08 (95% CI 0.87 to 1.33) for overweight women who had no MS, 3.01 (95% CI 2.30 to 3.94) for overweight women with MS, 1.58 (95% CI 1.21 to 2.08) for obese women without MS, and 2.89 (95% CI 2.19 to 3.80) for obese women with MS. Similar associations were evident for total coronary heart disease, but were not significant for total stroke. Overall, although C-reactive protein added additional prognostic information beyond BMI and MS, it did not fully account for the observed high risk of CVD associated with MS. In conclusion, MS may largely account for the increased risk of CVD associated with BMI in apparently healthy women.

Original languageEnglish (US)
Pages (from-to)1654-1658
Number of pages5
JournalAmerican Journal of Cardiology
Volume100
Issue number11
DOIs
StatePublished - Dec 1 2007
Externally publishedYes

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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