Comparison of younger and older breast cancer survivors and age-matched controls on specific and overall quality of life domains

Victoria Champion, Lynne I. Wagner, Patrick Monahan, Joanne Daggy, Lisa Smith, Andrea Cohee, Kim W. Ziner, Joan Haase, Kathy Miller, Kamnesh Pradhan, Frederick Unverzagt, David Cella, Bilal Ansari, George W. Sledge

Research output: Contribution to journalArticle

72 Citations (Scopus)

Abstract

BACKGROUND Younger survivors (YS) of breast cancer often report more survivorship symptoms such as fatigue, depression, sexual difficulty, and cognitive problems than older survivors (OS). This study sought to determine the effect of breast cancer and age at diagnosis on quality of life (QoL) by comparing 3 groups: 1) YS diagnosed at age 45 years or before, 2) OS diagnosed between 55 and 70, and 3) for the YSs, age-matched controls (AC) of women not diagnosed with breast cancer. METHODS Using a large Eastern Cooperative Oncology Group (ECOG) database, 505 YS were recruited who were aged 45 years or younger when diagnosed and 622 OS diagnosed at 55 to 70 years of age. YS, OS, and AC were compared on physical, psychological, social, spiritual, and overall QoL variables. RESULTS Compared to both AC and to OS, YS reported more depressive symptoms (P = .005) and fatigue (P < .001), poorer self-reported attention function (P < .001), and poorer sexual function (P < .001) than either comparison group. However, YS also reported a greater sense of personal growth (P < .001) and perceived less social constraint (P < .001) from their partner than AC. CONCLUSIONS YS reported worse functioning than AC relative to depression, fatigue, attention, sexual function, and spirituality. Perhaps even more important, YS fared worse than both AC and OS on body image, anxiety, sleep, marital satisfaction, and fear of recurrence, indicating that YS are at greater risk for long-term QoL problems than survivors diagnosed at a later age.

Original languageEnglish
Pages (from-to)2237-2246
Number of pages10
JournalCancer
Volume120
Issue number15
DOIs
StatePublished - Aug 1 2014

Fingerprint

Survivors
Quality of Life
Breast Neoplasms
Fatigue
Depression
Spirituality
Body Image
Fear
Sleep
Survival Rate
Anxiety
Databases

Keywords

  • breast cancer
  • comparison of older survivors
  • comparison of younger
  • quality of life
  • young survivors

ASJC Scopus subject areas

  • Cancer Research
  • Oncology
  • Medicine(all)

Cite this

Comparison of younger and older breast cancer survivors and age-matched controls on specific and overall quality of life domains. / Champion, Victoria; Wagner, Lynne I.; Monahan, Patrick; Daggy, Joanne; Smith, Lisa; Cohee, Andrea; Ziner, Kim W.; Haase, Joan; Miller, Kathy; Pradhan, Kamnesh; Unverzagt, Frederick; Cella, David; Ansari, Bilal; Sledge, George W.

In: Cancer, Vol. 120, No. 15, 01.08.2014, p. 2237-2246.

Research output: Contribution to journalArticle

@article{779b59f25dbe4de5b4910fc4f91c6c52,
title = "Comparison of younger and older breast cancer survivors and age-matched controls on specific and overall quality of life domains",
abstract = "BACKGROUND Younger survivors (YS) of breast cancer often report more survivorship symptoms such as fatigue, depression, sexual difficulty, and cognitive problems than older survivors (OS). This study sought to determine the effect of breast cancer and age at diagnosis on quality of life (QoL) by comparing 3 groups: 1) YS diagnosed at age 45 years or before, 2) OS diagnosed between 55 and 70, and 3) for the YSs, age-matched controls (AC) of women not diagnosed with breast cancer. METHODS Using a large Eastern Cooperative Oncology Group (ECOG) database, 505 YS were recruited who were aged 45 years or younger when diagnosed and 622 OS diagnosed at 55 to 70 years of age. YS, OS, and AC were compared on physical, psychological, social, spiritual, and overall QoL variables. RESULTS Compared to both AC and to OS, YS reported more depressive symptoms (P = .005) and fatigue (P < .001), poorer self-reported attention function (P < .001), and poorer sexual function (P < .001) than either comparison group. However, YS also reported a greater sense of personal growth (P < .001) and perceived less social constraint (P < .001) from their partner than AC. CONCLUSIONS YS reported worse functioning than AC relative to depression, fatigue, attention, sexual function, and spirituality. Perhaps even more important, YS fared worse than both AC and OS on body image, anxiety, sleep, marital satisfaction, and fear of recurrence, indicating that YS are at greater risk for long-term QoL problems than survivors diagnosed at a later age.",
keywords = "breast cancer, comparison of older survivors, comparison of younger, quality of life, young survivors",
author = "Victoria Champion and Wagner, {Lynne I.} and Patrick Monahan and Joanne Daggy and Lisa Smith and Andrea Cohee and Ziner, {Kim W.} and Joan Haase and Kathy Miller and Kamnesh Pradhan and Frederick Unverzagt and David Cella and Bilal Ansari and Sledge, {George W.}",
year = "2014",
month = "8",
day = "1",
doi = "10.1002/cncr.28737",
language = "English",
volume = "120",
pages = "2237--2246",
journal = "Cancer",
issn = "0008-543X",
publisher = "John Wiley and Sons Inc.",
number = "15",

}

TY - JOUR

T1 - Comparison of younger and older breast cancer survivors and age-matched controls on specific and overall quality of life domains

AU - Champion, Victoria

AU - Wagner, Lynne I.

AU - Monahan, Patrick

AU - Daggy, Joanne

AU - Smith, Lisa

AU - Cohee, Andrea

AU - Ziner, Kim W.

AU - Haase, Joan

AU - Miller, Kathy

AU - Pradhan, Kamnesh

AU - Unverzagt, Frederick

AU - Cella, David

AU - Ansari, Bilal

AU - Sledge, George W.

PY - 2014/8/1

Y1 - 2014/8/1

N2 - BACKGROUND Younger survivors (YS) of breast cancer often report more survivorship symptoms such as fatigue, depression, sexual difficulty, and cognitive problems than older survivors (OS). This study sought to determine the effect of breast cancer and age at diagnosis on quality of life (QoL) by comparing 3 groups: 1) YS diagnosed at age 45 years or before, 2) OS diagnosed between 55 and 70, and 3) for the YSs, age-matched controls (AC) of women not diagnosed with breast cancer. METHODS Using a large Eastern Cooperative Oncology Group (ECOG) database, 505 YS were recruited who were aged 45 years or younger when diagnosed and 622 OS diagnosed at 55 to 70 years of age. YS, OS, and AC were compared on physical, psychological, social, spiritual, and overall QoL variables. RESULTS Compared to both AC and to OS, YS reported more depressive symptoms (P = .005) and fatigue (P < .001), poorer self-reported attention function (P < .001), and poorer sexual function (P < .001) than either comparison group. However, YS also reported a greater sense of personal growth (P < .001) and perceived less social constraint (P < .001) from their partner than AC. CONCLUSIONS YS reported worse functioning than AC relative to depression, fatigue, attention, sexual function, and spirituality. Perhaps even more important, YS fared worse than both AC and OS on body image, anxiety, sleep, marital satisfaction, and fear of recurrence, indicating that YS are at greater risk for long-term QoL problems than survivors diagnosed at a later age.

AB - BACKGROUND Younger survivors (YS) of breast cancer often report more survivorship symptoms such as fatigue, depression, sexual difficulty, and cognitive problems than older survivors (OS). This study sought to determine the effect of breast cancer and age at diagnosis on quality of life (QoL) by comparing 3 groups: 1) YS diagnosed at age 45 years or before, 2) OS diagnosed between 55 and 70, and 3) for the YSs, age-matched controls (AC) of women not diagnosed with breast cancer. METHODS Using a large Eastern Cooperative Oncology Group (ECOG) database, 505 YS were recruited who were aged 45 years or younger when diagnosed and 622 OS diagnosed at 55 to 70 years of age. YS, OS, and AC were compared on physical, psychological, social, spiritual, and overall QoL variables. RESULTS Compared to both AC and to OS, YS reported more depressive symptoms (P = .005) and fatigue (P < .001), poorer self-reported attention function (P < .001), and poorer sexual function (P < .001) than either comparison group. However, YS also reported a greater sense of personal growth (P < .001) and perceived less social constraint (P < .001) from their partner than AC. CONCLUSIONS YS reported worse functioning than AC relative to depression, fatigue, attention, sexual function, and spirituality. Perhaps even more important, YS fared worse than both AC and OS on body image, anxiety, sleep, marital satisfaction, and fear of recurrence, indicating that YS are at greater risk for long-term QoL problems than survivors diagnosed at a later age.

KW - breast cancer

KW - comparison of older survivors

KW - comparison of younger

KW - quality of life

KW - young survivors

UR - http://www.scopus.com/inward/record.url?scp=84904768259&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84904768259&partnerID=8YFLogxK

U2 - 10.1002/cncr.28737

DO - 10.1002/cncr.28737

M3 - Article

VL - 120

SP - 2237

EP - 2246

JO - Cancer

JF - Cancer

SN - 0008-543X

IS - 15

ER -