Complement activation in discordant hepatic xenotransplantation

A. Joseph Tector, Xuwu Chen, Carl Soderland, Jean I. Tchervenkov

Research output: Contribution to journalArticle

14 Scopus citations

Abstract

Little is known about hyperacute rejection in hepatic xenotransplantation. Information from clinical xenoperfusions suggests that the liver may be rejected by a mechanism less vigorous than either kidney or heart xenografts. We used the in vitro model of porcine hepatic sinusoidal endothelial cells (PHEC) incubated with either complement replete or deficient human serum to determine the relative roles of the classical and alternate pathways of complement in the immediate response to hepatic xenotransplantation. Our results suggest that either the classical or alternate pathways are capable of independently activating the complement cascade upon exposure to the porcine hepatic sinusoidal endothelium. Our results also imply that either pathway alone is capable of initiating similar degrees of injury as the entire cascade.

Original languageEnglish (US)
Pages (from-to)257-261
Number of pages5
JournalXenotransplantation
Volume5
Issue number4
DOIs
StatePublished - Nov 1998

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Keywords

  • Complement
  • Endothelial injury
  • Liver
  • Xenograft

ASJC Scopus subject areas

  • Immunology
  • Transplantation

Cite this

Tector, A. J., Chen, X., Soderland, C., & Tchervenkov, J. I. (1998). Complement activation in discordant hepatic xenotransplantation. Xenotransplantation, 5(4), 257-261. https://doi.org/10.1111/j.1399-3089.1998.tb00036.x