Complement activation in discordant hepatic xenotransplantation

A. Joseph Tector, Xuwu Chen, Carl Soderland, Jean I. Tchervenkov

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Little is known about hyperacute rejection in hepatic xenotransplantation. Information from clinical xenoperfusions suggests that the liver may be rejected by a mechanism less vigorous than either kidney or heart xenografts. We used the in vitro model of porcine hepatic sinusoidal endothelial cells (PHEC) incubated with either complement replete or deficient human serum to determine the relative roles of the classical and alternate pathways of complement in the immediate response to hepatic xenotransplantation. Our results suggest that either the classical or alternate pathways are capable of independently activating the complement cascade upon exposure to the porcine hepatic sinusoidal endothelium. Our results also imply that either pathway alone is capable of initiating similar degrees of injury as the entire cascade.

Original languageEnglish (US)
Pages (from-to)257-261
Number of pages5
JournalXenotransplantation
Volume5
Issue number4
StatePublished - Nov 1998
Externally publishedYes

Fingerprint

Heterologous Transplantation
Complement Activation
Liver
Swine
Classical Complement Pathway
Heterografts
Endothelium
Endothelial Cells
Kidney
Wounds and Injuries
Serum

Keywords

  • Complement
  • Endothelial injury
  • Liver
  • Xenograft

ASJC Scopus subject areas

  • Immunology

Cite this

Tector, A. J., Chen, X., Soderland, C., & Tchervenkov, J. I. (1998). Complement activation in discordant hepatic xenotransplantation. Xenotransplantation, 5(4), 257-261.

Complement activation in discordant hepatic xenotransplantation. / Tector, A. Joseph; Chen, Xuwu; Soderland, Carl; Tchervenkov, Jean I.

In: Xenotransplantation, Vol. 5, No. 4, 11.1998, p. 257-261.

Research output: Contribution to journalArticle

Tector, AJ, Chen, X, Soderland, C & Tchervenkov, JI 1998, 'Complement activation in discordant hepatic xenotransplantation', Xenotransplantation, vol. 5, no. 4, pp. 257-261.
Tector AJ, Chen X, Soderland C, Tchervenkov JI. Complement activation in discordant hepatic xenotransplantation. Xenotransplantation. 1998 Nov;5(4):257-261.
Tector, A. Joseph ; Chen, Xuwu ; Soderland, Carl ; Tchervenkov, Jean I. / Complement activation in discordant hepatic xenotransplantation. In: Xenotransplantation. 1998 ; Vol. 5, No. 4. pp. 257-261.
@article{e882c1bdbeff47c99c44eebb851e5337,
title = "Complement activation in discordant hepatic xenotransplantation",
abstract = "Little is known about hyperacute rejection in hepatic xenotransplantation. Information from clinical xenoperfusions suggests that the liver may be rejected by a mechanism less vigorous than either kidney or heart xenografts. We used the in vitro model of porcine hepatic sinusoidal endothelial cells (PHEC) incubated with either complement replete or deficient human serum to determine the relative roles of the classical and alternate pathways of complement in the immediate response to hepatic xenotransplantation. Our results suggest that either the classical or alternate pathways are capable of independently activating the complement cascade upon exposure to the porcine hepatic sinusoidal endothelium. Our results also imply that either pathway alone is capable of initiating similar degrees of injury as the entire cascade.",
keywords = "Complement, Endothelial injury, Liver, Xenograft",
author = "Tector, {A. Joseph} and Xuwu Chen and Carl Soderland and Tchervenkov, {Jean I.}",
year = "1998",
month = "11",
language = "English (US)",
volume = "5",
pages = "257--261",
journal = "Xenotransplantation",
issn = "0908-665X",
publisher = "Wiley-Blackwell",
number = "4",

}

TY - JOUR

T1 - Complement activation in discordant hepatic xenotransplantation

AU - Tector, A. Joseph

AU - Chen, Xuwu

AU - Soderland, Carl

AU - Tchervenkov, Jean I.

PY - 1998/11

Y1 - 1998/11

N2 - Little is known about hyperacute rejection in hepatic xenotransplantation. Information from clinical xenoperfusions suggests that the liver may be rejected by a mechanism less vigorous than either kidney or heart xenografts. We used the in vitro model of porcine hepatic sinusoidal endothelial cells (PHEC) incubated with either complement replete or deficient human serum to determine the relative roles of the classical and alternate pathways of complement in the immediate response to hepatic xenotransplantation. Our results suggest that either the classical or alternate pathways are capable of independently activating the complement cascade upon exposure to the porcine hepatic sinusoidal endothelium. Our results also imply that either pathway alone is capable of initiating similar degrees of injury as the entire cascade.

AB - Little is known about hyperacute rejection in hepatic xenotransplantation. Information from clinical xenoperfusions suggests that the liver may be rejected by a mechanism less vigorous than either kidney or heart xenografts. We used the in vitro model of porcine hepatic sinusoidal endothelial cells (PHEC) incubated with either complement replete or deficient human serum to determine the relative roles of the classical and alternate pathways of complement in the immediate response to hepatic xenotransplantation. Our results suggest that either the classical or alternate pathways are capable of independently activating the complement cascade upon exposure to the porcine hepatic sinusoidal endothelium. Our results also imply that either pathway alone is capable of initiating similar degrees of injury as the entire cascade.

KW - Complement

KW - Endothelial injury

KW - Liver

KW - Xenograft

UR - http://www.scopus.com/inward/record.url?scp=0032436648&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0032436648&partnerID=8YFLogxK

M3 - Article

C2 - 9915253

AN - SCOPUS:0032436648

VL - 5

SP - 257

EP - 261

JO - Xenotransplantation

JF - Xenotransplantation

SN - 0908-665X

IS - 4

ER -