Complement system in lung disease

Pankita H. Pandya, David S. Wilkes

Research output: Contribution to journalReview article

16 Scopus citations

Abstract

In addition to its established contribution to innate immunity, recent studies have suggested novel roles for the complement system in the development of various lung diseases. Several studies have demonstrated that complement may serve as a key link between innate and adaptive immunity in a variety of pulmonary conditions. However, the specific contributions of complement to lung diseases based on innate and adaptive immunity are just beginning to emerge. Elucidating the role of complement-mediated immune regulation in these diseases will help to identify new targets for therapeutic interventions.

Original languageEnglish (US)
Pages (from-to)467-473
Number of pages7
JournalAmerican journal of respiratory cell and molecular biology
Volume51
Issue number4
DOIs
StatePublished - Oct 1 2014

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Keywords

  • Fibrosis
  • Immune complexes
  • Immunology
  • Transplantation

ASJC Scopus subject areas

  • Cell Biology
  • Pulmonary and Respiratory Medicine
  • Molecular Biology
  • Clinical Biochemistry
  • Medicine(all)

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