Complement system in lung disease

Pankita H. Pandya, David S. Wilkes

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

In addition to its established contribution to innate immunity, recent studies have suggested novel roles for the complement system in the development of various lung diseases. Several studies have demonstrated that complement may serve as a key link between innate and adaptive immunity in a variety of pulmonary conditions. However, the specific contributions of complement to lung diseases based on innate and adaptive immunity are just beginning to emerge. Elucidating the role of complement-mediated immune regulation in these diseases will help to identify new targets for therapeutic interventions.

Original languageEnglish
Pages (from-to)467-473
Number of pages7
JournalAmerican Journal of Respiratory Cell and Molecular Biology
Volume51
Issue number4
DOIs
StatePublished - Oct 1 2014

Fingerprint

Pulmonary diseases
Innate Immunity
Lung Diseases
Adaptive Immunity
Lung
Therapeutics

Keywords

  • Fibrosis
  • Immune complexes
  • Immunology
  • Transplantation

ASJC Scopus subject areas

  • Cell Biology
  • Pulmonary and Respiratory Medicine
  • Molecular Biology
  • Clinical Biochemistry
  • Medicine(all)

Cite this

Complement system in lung disease. / Pandya, Pankita H.; Wilkes, David S.

In: American Journal of Respiratory Cell and Molecular Biology, Vol. 51, No. 4, 01.10.2014, p. 467-473.

Research output: Contribution to journalArticle

Pandya, Pankita H. ; Wilkes, David S. / Complement system in lung disease. In: American Journal of Respiratory Cell and Molecular Biology. 2014 ; Vol. 51, No. 4. pp. 467-473.
@article{0a6c5132737540ed959aaeda0955fb0d,
title = "Complement system in lung disease",
abstract = "In addition to its established contribution to innate immunity, recent studies have suggested novel roles for the complement system in the development of various lung diseases. Several studies have demonstrated that complement may serve as a key link between innate and adaptive immunity in a variety of pulmonary conditions. However, the specific contributions of complement to lung diseases based on innate and adaptive immunity are just beginning to emerge. Elucidating the role of complement-mediated immune regulation in these diseases will help to identify new targets for therapeutic interventions.",
keywords = "Fibrosis, Immune complexes, Immunology, Transplantation",
author = "Pandya, {Pankita H.} and Wilkes, {David S.}",
year = "2014",
month = "10",
day = "1",
doi = "10.1165/rcmb.2013-0485TR",
language = "English",
volume = "51",
pages = "467--473",
journal = "American Journal of Respiratory Cell and Molecular Biology",
issn = "1044-1549",
publisher = "American Thoracic Society",
number = "4",

}

TY - JOUR

T1 - Complement system in lung disease

AU - Pandya, Pankita H.

AU - Wilkes, David S.

PY - 2014/10/1

Y1 - 2014/10/1

N2 - In addition to its established contribution to innate immunity, recent studies have suggested novel roles for the complement system in the development of various lung diseases. Several studies have demonstrated that complement may serve as a key link between innate and adaptive immunity in a variety of pulmonary conditions. However, the specific contributions of complement to lung diseases based on innate and adaptive immunity are just beginning to emerge. Elucidating the role of complement-mediated immune regulation in these diseases will help to identify new targets for therapeutic interventions.

AB - In addition to its established contribution to innate immunity, recent studies have suggested novel roles for the complement system in the development of various lung diseases. Several studies have demonstrated that complement may serve as a key link between innate and adaptive immunity in a variety of pulmonary conditions. However, the specific contributions of complement to lung diseases based on innate and adaptive immunity are just beginning to emerge. Elucidating the role of complement-mediated immune regulation in these diseases will help to identify new targets for therapeutic interventions.

KW - Fibrosis

KW - Immune complexes

KW - Immunology

KW - Transplantation

UR - http://www.scopus.com/inward/record.url?scp=84907513243&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84907513243&partnerID=8YFLogxK

U2 - 10.1165/rcmb.2013-0485TR

DO - 10.1165/rcmb.2013-0485TR

M3 - Article

C2 - 24901241

AN - SCOPUS:84907513243

VL - 51

SP - 467

EP - 473

JO - American Journal of Respiratory Cell and Molecular Biology

JF - American Journal of Respiratory Cell and Molecular Biology

SN - 1044-1549

IS - 4

ER -