Complex Genetics of Alcoholism

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Citations (Scopus)

Abstract

Genetic factors play a significant role in the risk for alcoholism, although environmental influences are also important. Alcohol use disorders are defined by symptomology and are heterogeneous, making the identification of specific genes that affect risk difficult. Several strategies have been applied to identify genes that contribute to alcoholism and alcohol-related phenotypes, including candidate gene studies, family-based linkage studies, and genome-wide association studies. Variants in the alcohol metabolizing genes ALDH2 and ADH1B confer some protection against alcohol dependence. Common variants in other genes, including ADH4, ADH1C, GABRA2, GABRG1, CHRNA5, CHRNA3, CHRM2, PECR, AUTS2, PDYN, OPRK1, and KCNJ6, have been associated with alcohol dependence or other alcohol-related phenotypes. Many of these results await further replication. Meta-analysis of large datasets is ongoing and will be critical to the identification of additional loci. Sequencing approaches are underway to identify rare variants contributing to alcoholism and alcohol-related traits.

Original languageEnglish
Title of host publicationNeurobiology of Alcohol Dependence
PublisherElsevier Inc.
Pages539-550
Number of pages12
ISBN (Print)9780124059412
DOIs
StatePublished - Feb 2014

Fingerprint

Alcoholism
Alcohols
Genes
Phenotype
Genome-Wide Association Study
Meta-Analysis

Keywords

  • Alcohol dehydrogenase
  • Alcohol dependence
  • Aldehyde dehydrogenase
  • Common variants
  • Endophenotype
  • Genetics
  • Genome-wide association study
  • Nicotinic receptors
  • Opioid receptors
  • Rare variants

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Edenberg, H., & Foroud, T. (2014). Complex Genetics of Alcoholism. In Neurobiology of Alcohol Dependence (pp. 539-550). Elsevier Inc.. https://doi.org/10.1016/B978-0-12-405941-2.00026-2

Complex Genetics of Alcoholism. / Edenberg, Howard; Foroud, Tatiana.

Neurobiology of Alcohol Dependence. Elsevier Inc., 2014. p. 539-550.

Research output: Chapter in Book/Report/Conference proceedingChapter

Edenberg, H & Foroud, T 2014, Complex Genetics of Alcoholism. in Neurobiology of Alcohol Dependence. Elsevier Inc., pp. 539-550. https://doi.org/10.1016/B978-0-12-405941-2.00026-2
Edenberg H, Foroud T. Complex Genetics of Alcoholism. In Neurobiology of Alcohol Dependence. Elsevier Inc. 2014. p. 539-550 https://doi.org/10.1016/B978-0-12-405941-2.00026-2
Edenberg, Howard ; Foroud, Tatiana. / Complex Genetics of Alcoholism. Neurobiology of Alcohol Dependence. Elsevier Inc., 2014. pp. 539-550
@inbook{f19934a41a744a6b9784878a99e657d9,
title = "Complex Genetics of Alcoholism",
abstract = "Genetic factors play a significant role in the risk for alcoholism, although environmental influences are also important. Alcohol use disorders are defined by symptomology and are heterogeneous, making the identification of specific genes that affect risk difficult. Several strategies have been applied to identify genes that contribute to alcoholism and alcohol-related phenotypes, including candidate gene studies, family-based linkage studies, and genome-wide association studies. Variants in the alcohol metabolizing genes ALDH2 and ADH1B confer some protection against alcohol dependence. Common variants in other genes, including ADH4, ADH1C, GABRA2, GABRG1, CHRNA5, CHRNA3, CHRM2, PECR, AUTS2, PDYN, OPRK1, and KCNJ6, have been associated with alcohol dependence or other alcohol-related phenotypes. Many of these results await further replication. Meta-analysis of large datasets is ongoing and will be critical to the identification of additional loci. Sequencing approaches are underway to identify rare variants contributing to alcoholism and alcohol-related traits.",
keywords = "Alcohol dehydrogenase, Alcohol dependence, Aldehyde dehydrogenase, Common variants, Endophenotype, Genetics, Genome-wide association study, Nicotinic receptors, Opioid receptors, Rare variants",
author = "Howard Edenberg and Tatiana Foroud",
year = "2014",
month = "2",
doi = "10.1016/B978-0-12-405941-2.00026-2",
language = "English",
isbn = "9780124059412",
pages = "539--550",
booktitle = "Neurobiology of Alcohol Dependence",
publisher = "Elsevier Inc.",

}

TY - CHAP

T1 - Complex Genetics of Alcoholism

AU - Edenberg, Howard

AU - Foroud, Tatiana

PY - 2014/2

Y1 - 2014/2

N2 - Genetic factors play a significant role in the risk for alcoholism, although environmental influences are also important. Alcohol use disorders are defined by symptomology and are heterogeneous, making the identification of specific genes that affect risk difficult. Several strategies have been applied to identify genes that contribute to alcoholism and alcohol-related phenotypes, including candidate gene studies, family-based linkage studies, and genome-wide association studies. Variants in the alcohol metabolizing genes ALDH2 and ADH1B confer some protection against alcohol dependence. Common variants in other genes, including ADH4, ADH1C, GABRA2, GABRG1, CHRNA5, CHRNA3, CHRM2, PECR, AUTS2, PDYN, OPRK1, and KCNJ6, have been associated with alcohol dependence or other alcohol-related phenotypes. Many of these results await further replication. Meta-analysis of large datasets is ongoing and will be critical to the identification of additional loci. Sequencing approaches are underway to identify rare variants contributing to alcoholism and alcohol-related traits.

AB - Genetic factors play a significant role in the risk for alcoholism, although environmental influences are also important. Alcohol use disorders are defined by symptomology and are heterogeneous, making the identification of specific genes that affect risk difficult. Several strategies have been applied to identify genes that contribute to alcoholism and alcohol-related phenotypes, including candidate gene studies, family-based linkage studies, and genome-wide association studies. Variants in the alcohol metabolizing genes ALDH2 and ADH1B confer some protection against alcohol dependence. Common variants in other genes, including ADH4, ADH1C, GABRA2, GABRG1, CHRNA5, CHRNA3, CHRM2, PECR, AUTS2, PDYN, OPRK1, and KCNJ6, have been associated with alcohol dependence or other alcohol-related phenotypes. Many of these results await further replication. Meta-analysis of large datasets is ongoing and will be critical to the identification of additional loci. Sequencing approaches are underway to identify rare variants contributing to alcoholism and alcohol-related traits.

KW - Alcohol dehydrogenase

KW - Alcohol dependence

KW - Aldehyde dehydrogenase

KW - Common variants

KW - Endophenotype

KW - Genetics

KW - Genome-wide association study

KW - Nicotinic receptors

KW - Opioid receptors

KW - Rare variants

UR - http://www.scopus.com/inward/record.url?scp=84902412230&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84902412230&partnerID=8YFLogxK

U2 - 10.1016/B978-0-12-405941-2.00026-2

DO - 10.1016/B978-0-12-405941-2.00026-2

M3 - Chapter

AN - SCOPUS:84902412230

SN - 9780124059412

SP - 539

EP - 550

BT - Neurobiology of Alcohol Dependence

PB - Elsevier Inc.

ER -