Complications among colorectal cancer survivors: SF-6D preference-weighted quality of life scores

Mark C. Hornbrook, Christopher S. Wendel, Stephen Joel Coons, Marcia Grant, Lisa J. Herrinton, M. Jane Mohler, Carol M. Baldwin, Carmit K. McMullen, Sylvan B. Green, Andrea Altschuler, Susan M. Rawl, Robert S. Krouse

Research output: Contribution to journalArticle

27 Scopus citations

Abstract

Background: Societal preference-weighted health-related quality of life (HRQOL) scores enable comparing multidimensional health states across diseases and treatments for research and policy. Objective: To assess the effects of living with a permanent intestinal stoma, compared with a major bowel resection, among colorectal cancer (CRC) survivors. Research Design: Cross-sectional multivariate linear regression analysis to explain preference-weighted HRQOL scores. Subjects: In all, 640 CRC survivors (5 years) from 3 group model health maintenance organizations; ostomates and nonostomates with colorectal resections for CRC were matched on gender, age (±5 years), time since diagnosis, and tumor site (rectum vs. colon). Measures: SF-6D scoring system was applied to Medical Outcomes Study Short Form-36 version 2 (SF-36v2); City of Hope Quality of Life-Ostomy; and Charlson-Deyo comorbidity index. Methods: Survey of CRC survivors linked to respondents' clinical data extracted from health maintenance organization files. Results: Response rate was 52%. Ostomates and nonostomates had similar sociodemographic characteristics. Mean SF-6D score was 0.69 for ostomates, compared with 0.73 for nonostomates (P < 0.001), but other factors explained this difference. Complications of initial cancer surgery, and previous year comorbidity burden, and hospital use were negatively associated with SF-6D scores, whereas household income was positively associated. Conclusions: CRC survivors' SF-6D scores were not associated with living with a permanent ostomy after other factors were taken into account. Surgical complications, comorbidities, and metastatic disease lowered the preference-weighted HRQOL of CRC survivors with and without ostomies. Further research to understand and reduce late complications from CRC surgeries as well as associated depression is warranted.

Original languageEnglish (US)
Pages (from-to)321-326
Number of pages6
JournalMedical care
Volume49
Issue number3
DOIs
StatePublished - Mar 2011

Keywords

  • HRQOL
  • colorectal cancer
  • ostomies
  • stomas
  • survivorship
  • utilities

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health

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    Hornbrook, M. C., Wendel, C. S., Coons, S. J., Grant, M., Herrinton, L. J., Mohler, M. J., Baldwin, C. M., McMullen, C. K., Green, S. B., Altschuler, A., Rawl, S. M., & Krouse, R. S. (2011). Complications among colorectal cancer survivors: SF-6D preference-weighted quality of life scores. Medical care, 49(3), 321-326. https://doi.org/10.1097/MLR.0b013e31820194c8