Composite intestinal adenoma-microcarcinoid

Jingmei Lin, John R. Goldblum, Ana E. Bennett, Mary P. Bronner, Xiuli Liu

Research output: Contribution to journalArticle

12 Scopus citations


Composite intestinal adenoma and microcarcinoid is a rare intestinal neoplasm consisting of intermingled adenomatous and well-differentiated neuroendocrine components. A few case reports and small series have suggested an indolent clinical course for this entity. We reported 7 cases of composite intestinal adenoma-microcarcinoid, including their morphologic features and clinical follow-up, both in biopsy and resection specimens. We identified 7 cases of composite intestinal adenoma-microcarcinoid from our pathology database. Five were from the large intestine, and 2 were in the duodenum. Morphologically, all microcarcinoids exhibited low-grade cytologic atypia and were devoid of significant pleomorphism, necrosis, and mitotic activity. Among the 7 lesions, 6 had a lobular architecture with smooth borders and mucosa-confined microcarcinoids; none had neuroendocrine carcinoma in subsequent resections. However, 1 colonic case had carcinoid cells penetrating the muscularis mucosae into the submucosa with an infiltrative border, and the resection showed metastatic highgrade neuroendocrine carcinoma in 1 lymph node. Composite intestinal adenoma-microcarcinoid is extremely rare. Although composite mucosa-confined adenoma-microcarcinoid is likely to have an indolent behavior, submucosal invasion by the neuroendocrine component may be associated with aggressive behavior.

Original languageEnglish (US)
Pages (from-to)292-295
Number of pages4
JournalAmerican Journal of Surgical Pathology
Issue number2
StatePublished - Feb 1 2012


  • Adenoma
  • Carcinoid
  • Composite neuroendocrine tumor
  • Endocrine cell proliferation
  • Microcarcinoid

ASJC Scopus subject areas

  • Anatomy
  • Pathology and Forensic Medicine
  • Surgery
  • Medicine(all)

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  • Cite this

    Lin, J., Goldblum, J. R., Bennett, A. E., Bronner, M. P., & Liu, X. (2012). Composite intestinal adenoma-microcarcinoid. American Journal of Surgical Pathology, 36(2), 292-295.