Comprehensive assessment of retinal, choroidal and retrobulbar haemodynamics during blood gas perturbation

Emma J. Roff, Alon Harris, Hak Sung Chung, Sarah L. Hosking, Alexandra M. Morrison, Paul J. Halter, Larry Kagemann

Research output: Contribution to journalArticle

41 Citations (Scopus)

Abstract

- Background: A study was performed to evaluate the effect of isoxic hypercapnia on ocular haemodynamics using colour Doppler imaging (CDI), scanning laser Doppler flowmetry (SLDF) and ocular blood flow (OBF) tonography. - Methods: Measurements were taken for one eye of each of 14 healthy subjects (mean age 27 ± 6 years) during breathing of room air and then during isoxic hypercapnia (breathing CO2 and room air). Using CDI, blood flow velocities and resistance indices were determined for the ophthalmic artery (OA), central retinal artery (CRA) and short posterior ciliary arteries (SPCAs). Using SLDF a 10 x 10 pixel frame was used to measure blood flow, volume and velocity in each quadrant of the peripapillary retina. Pulsatile ocular blood flow (POBF) was measured using the OBF tonograph. - Results: Using CDI, peak systolic and end diastolic velocities increased and resistance index decreased significantly in the SPCAs during hypercapnia. Using SLDF, blood flow volume and velocity increased significantly during hypercapnia in the superior temporal quadrant of the peripapillary retina. No significant difference was observed between baseline and hypercapnia for POBF. - Conclusions: Isoxic hypercapnia resulted in an increase in peripapillary retinal and SPCA blood flow parameters as determined by SLDF and CDI respectively. This implies the presence of autoregulatory activity in these vasculatures. These findings may be of significance in the pathogenesis of ocular disease such as glaucoma where autoregulation is thought to be compromised.

Original languageEnglish
Pages (from-to)984-990
Number of pages7
JournalGraefe's Archive for Clinical and Experimental Ophthalmology
Volume237
Issue number12
DOIs
StatePublished - Dec 1999

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Hypercapnia
Laser-Doppler Flowmetry
Gases
Hemodynamics
Ciliary Arteries
Blood Flow Velocity
Color
Blood Volume
Retina
Respiration
Air
Ophthalmic Artery
Retinal Artery
Eye Diseases
Glaucoma
Healthy Volunteers
Homeostasis

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Comprehensive assessment of retinal, choroidal and retrobulbar haemodynamics during blood gas perturbation. / Roff, Emma J.; Harris, Alon; Chung, Hak Sung; Hosking, Sarah L.; Morrison, Alexandra M.; Halter, Paul J.; Kagemann, Larry.

In: Graefe's Archive for Clinical and Experimental Ophthalmology, Vol. 237, No. 12, 12.1999, p. 984-990.

Research output: Contribution to journalArticle

Roff, Emma J. ; Harris, Alon ; Chung, Hak Sung ; Hosking, Sarah L. ; Morrison, Alexandra M. ; Halter, Paul J. ; Kagemann, Larry. / Comprehensive assessment of retinal, choroidal and retrobulbar haemodynamics during blood gas perturbation. In: Graefe's Archive for Clinical and Experimental Ophthalmology. 1999 ; Vol. 237, No. 12. pp. 984-990.
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