Comprehensive vs. Assisted Management of Mood and Pain Symptoms (CAMMPS) trial: Study design and sample characteristics

Kurt Kroenke, Erica Evans, Sharon Weitlauf, Stephanie McCalley, Brian Porter, Tabeel Williams, Fitsum Baye, Spencer G. Lourens, Marianne S. Matthias, Matthew J. Bair

Research output: Contribution to journalArticlepeer-review

11 Scopus citations


Background Pain is the most common presenting somatic symptom in medical outpatients, and depression and anxiety are the two most common mental disorders. They frequently co-occur, are under-treated, and result in substantial disability and reduced health-related quality of life. Objectives The Comprehensive vs. Assisted Management of Mood and Pain Symptoms (CAMMPS) study is a randomized comparative effectiveness trial designed to test the relative effectiveness of a lower-resource vs. a higher-resource technology-assisted intervention for the management of patients suffering from pain plus anxiety and/or depression. Methods/design CAMMPS has enrolled 294 primary care patients with chronic pain plus comorbid anxiety and/or depression and randomized them to either: 1) Assisted Symptom Management (ASM) consisting of automated symptom monitoring by interactive voice recording or Internet and prompted pain and mood self-management; or 2) Comprehensive Symptom Management (CSM) which combines ASM with optimized medication management delivered by a nurse-physician specialist team and facilitated mental health care. Outcomes are assessed at baseline, 1, 3, 6, and 12 months. The primary outcome is a composite pain-anxiety-depression (PAD) severity score. Secondary outcomes include individual pain, anxiety, and depression scores, health-related quality of life, disability, healthcare utilization, and treatment satisfaction. Discussion CAMMPS provides an integrated approach to PAD symptoms rather than fragmented care of single symptoms; coordinated symptom management in partnership with primary care clinicians and psychologists embedded in primary care; efficient use of health information technology; attention to physical and psychological symptom comorbidity; and the coupling of self-management with optimized medication management and facilitated mental health care. Trial registration Identifier: NCT01757301.

Original languageEnglish (US)
Pages (from-to)179-187
Number of pages9
JournalContemporary Clinical Trials
StatePublished - Jan 2018


  • Anxiety
  • Clinical trial
  • Depression
  • Pain
  • Patient-reported outcome
  • Telehealth
  • Telemedicine

ASJC Scopus subject areas

  • Pharmacology (medical)

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