Computational approaches to studying thrombus development

Zhiliang Xu, Malgorzata Kamocka, Mark Alber, Elliot Rosen

Research output: Contribution to journalArticle

45 Citations (Scopus)

Abstract

In addition to descriptive biological models, many computational models have been developed for hemostasis/thrombosis that provide quantitative characterization of thrombus development. Simulations using computational models that have been developed for coagulation reactions, platelet activation, and fibrinogen assembly have been shown to be in close agreement with experimental data. Models of processes involved in hemostasis/thrombosis are being integrated to simulate the development of the thrombus simultaneously in time and space. Further development of computational approaches can provide quantitative insights leading to predictions that are not obvious from qualitative biological models.

Original languageEnglish
Pages (from-to)500-505
Number of pages6
JournalArteriosclerosis, Thrombosis, and Vascular Biology
Volume31
Issue number3
DOIs
StatePublished - Mar 2011

Fingerprint

Thrombosis
Biological Models
Hemostasis
Platelet Activation
Fibrinogen

Keywords

  • blood coagulation
  • blood flow
  • coagulation
  • computational model
  • platelets
  • stochastic multiscale model
  • thrombosis
  • thrombus development

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Computational approaches to studying thrombus development. / Xu, Zhiliang; Kamocka, Malgorzata; Alber, Mark; Rosen, Elliot.

In: Arteriosclerosis, Thrombosis, and Vascular Biology, Vol. 31, No. 3, 03.2011, p. 500-505.

Research output: Contribution to journalArticle

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