Computational approaches to studying thrombus development

Zhiliang Xu, Malgorzata Kamocka, Mark Alber, Elliot D. Rosen

Research output: Contribution to journalArticle

47 Scopus citations

Abstract

In addition to descriptive biological models, many computational models have been developed for hemostasis/thrombosis that provide quantitative characterization of thrombus development. Simulations using computational models that have been developed for coagulation reactions, platelet activation, and fibrinogen assembly have been shown to be in close agreement with experimental data. Models of processes involved in hemostasis/thrombosis are being integrated to simulate the development of the thrombus simultaneously in time and space. Further development of computational approaches can provide quantitative insights leading to predictions that are not obvious from qualitative biological models.

Original languageEnglish (US)
Pages (from-to)500-505
Number of pages6
JournalArteriosclerosis, thrombosis, and vascular biology
Volume31
Issue number3
DOIs
StatePublished - Mar 1 2011

Keywords

  • blood coagulation
  • blood flow
  • coagulation
  • computational model
  • platelets
  • stochastic multiscale model
  • thrombosis
  • thrombus development

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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