Computed tomographic, neurologic, and neuropsychological correlates of huntington's disease

Daniel S. Sax, Brian O'Donnell, Nelson Butters, Leon Menzer, Kathleen Montgomery, Herbert L. Kayne

Research output: Contribution to journalArticle

42 Citations (Scopus)

Abstract

Twenty-six patients with Huntington's disease (HD) and three subjects at risk for HD were evaluated by computed tomographic, neurologic and neuropsychological examinations. These data were used to delineate the sequence of structural changes in early and intermediate HD, and the relationship of these changes to impairment of neurologic and cognitive function. CT scans documented an early neostriatal-frontal focus of atrophy in HD which spreads caudally over the cerebral cortex during the course of the disease. Chorea was positively correlated with caudate atrophy. Functional and cognitive (especially memory and visuospatial) impairments were strongly related to the degree of atrophy. Multiple regression analyses of CT and neuropsychological data further demonstrated that neostriatal changes make a significant contribution to the cognitive as well as to the motor impairments of HD patients.

Original languageEnglish (US)
Pages (from-to)21-36
Number of pages16
JournalInternational Journal of Neuroscience
Volume18
Issue number1-2
DOIs
StatePublished - 1983
Externally publishedYes

Fingerprint

Huntington Disease
Nervous System
Atrophy
Chorea
Neurologic Examination
Cerebral Cortex
Cognition
Regression Analysis

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Computed tomographic, neurologic, and neuropsychological correlates of huntington's disease. / Sax, Daniel S.; O'Donnell, Brian; Butters, Nelson; Menzer, Leon; Montgomery, Kathleen; Kayne, Herbert L.

In: International Journal of Neuroscience, Vol. 18, No. 1-2, 1983, p. 21-36.

Research output: Contribution to journalArticle

Sax, Daniel S. ; O'Donnell, Brian ; Butters, Nelson ; Menzer, Leon ; Montgomery, Kathleen ; Kayne, Herbert L. / Computed tomographic, neurologic, and neuropsychological correlates of huntington's disease. In: International Journal of Neuroscience. 1983 ; Vol. 18, No. 1-2. pp. 21-36.
@article{17968d417c8149a79b28fbdc3ef0fea9,
title = "Computed tomographic, neurologic, and neuropsychological correlates of huntington's disease",
abstract = "Twenty-six patients with Huntington's disease (HD) and three subjects at risk for HD were evaluated by computed tomographic, neurologic and neuropsychological examinations. These data were used to delineate the sequence of structural changes in early and intermediate HD, and the relationship of these changes to impairment of neurologic and cognitive function. CT scans documented an early neostriatal-frontal focus of atrophy in HD which spreads caudally over the cerebral cortex during the course of the disease. Chorea was positively correlated with caudate atrophy. Functional and cognitive (especially memory and visuospatial) impairments were strongly related to the degree of atrophy. Multiple regression analyses of CT and neuropsychological data further demonstrated that neostriatal changes make a significant contribution to the cognitive as well as to the motor impairments of HD patients.",
author = "Sax, {Daniel S.} and Brian O'Donnell and Nelson Butters and Leon Menzer and Kathleen Montgomery and Kayne, {Herbert L.}",
year = "1983",
doi = "10.3109/00207458308985874",
language = "English (US)",
volume = "18",
pages = "21--36",
journal = "International Journal of Neuroscience",
issn = "0020-7454",
publisher = "Informa Healthcare",
number = "1-2",

}

TY - JOUR

T1 - Computed tomographic, neurologic, and neuropsychological correlates of huntington's disease

AU - Sax, Daniel S.

AU - O'Donnell, Brian

AU - Butters, Nelson

AU - Menzer, Leon

AU - Montgomery, Kathleen

AU - Kayne, Herbert L.

PY - 1983

Y1 - 1983

N2 - Twenty-six patients with Huntington's disease (HD) and three subjects at risk for HD were evaluated by computed tomographic, neurologic and neuropsychological examinations. These data were used to delineate the sequence of structural changes in early and intermediate HD, and the relationship of these changes to impairment of neurologic and cognitive function. CT scans documented an early neostriatal-frontal focus of atrophy in HD which spreads caudally over the cerebral cortex during the course of the disease. Chorea was positively correlated with caudate atrophy. Functional and cognitive (especially memory and visuospatial) impairments were strongly related to the degree of atrophy. Multiple regression analyses of CT and neuropsychological data further demonstrated that neostriatal changes make a significant contribution to the cognitive as well as to the motor impairments of HD patients.

AB - Twenty-six patients with Huntington's disease (HD) and three subjects at risk for HD were evaluated by computed tomographic, neurologic and neuropsychological examinations. These data were used to delineate the sequence of structural changes in early and intermediate HD, and the relationship of these changes to impairment of neurologic and cognitive function. CT scans documented an early neostriatal-frontal focus of atrophy in HD which spreads caudally over the cerebral cortex during the course of the disease. Chorea was positively correlated with caudate atrophy. Functional and cognitive (especially memory and visuospatial) impairments were strongly related to the degree of atrophy. Multiple regression analyses of CT and neuropsychological data further demonstrated that neostriatal changes make a significant contribution to the cognitive as well as to the motor impairments of HD patients.

UR - http://www.scopus.com/inward/record.url?scp=0020702034&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0020702034&partnerID=8YFLogxK

U2 - 10.3109/00207458308985874

DO - 10.3109/00207458308985874

M3 - Article

VL - 18

SP - 21

EP - 36

JO - International Journal of Neuroscience

JF - International Journal of Neuroscience

SN - 0020-7454

IS - 1-2

ER -