Computed tomography score and pulmonary function in infants with chronic lung disease of infancy

E. E. Sarria, R. Mattiello, L. Rao, Matthew Wanner, M. E. Raske, C. Tiller, R. Kimmel, Robert Tepper

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Chronic lung disease of infancy (CLDI) remains a common outcome among infants born extremely prematurely. In older children and adults with lung disease, pulmonary function and computed tomography (CT) scores are used to follow up respiratory disease and assess disease severity. For infants and toddlers, however, these outcomes have been used very infrequently and most often, a dichotomous respiratory outcome (presence or absence of CLDI) is employed. We evaluated the performance of CT score and pulmonary function to differentiate infants and toddlers with CLDI from a control group. CT scans, forced expiratory flows and pulmonary diffusing capacity were obtained in 39 CLDI patients and 41 controls (aged 4-33 months). CT scans were quantified using a scoring system, while pulmonary function was expressed as Z-scores. CT score outperformed pulmonary function in identifying those with CLDI. There were no significant correlations between CT score and pulmonary function. CT score had a better performance than pulmonary function in differentiating individuals with CLDI; however, these outcomes may reflect differing components of the pulmonary pathophysiology of CLDI. This new information on pulmonary outcomes can assist in designing studies with these parameters. Future studies will be required to evaluate which of the outcomes can better detect improvement with therapeutic intervention and/or lung growth. Copyright

Original languageEnglish
Pages (from-to)918-923
Number of pages6
JournalEuropean Respiratory Journal
Volume38
Issue number4
DOIs
StatePublished - Oct 1 2011

Fingerprint

Lung Diseases
Chronic Disease
Tomography
Lung
Pulmonary Diffusing Capacity
Control Groups
Growth

Keywords

  • Bronchopulmonary dysplasia
  • Forced expiratory flows
  • High-resolution computed tomography
  • Lung function
  • Pulmonary diffusing capacity

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

Cite this

Computed tomography score and pulmonary function in infants with chronic lung disease of infancy. / Sarria, E. E.; Mattiello, R.; Rao, L.; Wanner, Matthew; Raske, M. E.; Tiller, C.; Kimmel, R.; Tepper, Robert.

In: European Respiratory Journal, Vol. 38, No. 4, 01.10.2011, p. 918-923.

Research output: Contribution to journalArticle

Sarria, E. E. ; Mattiello, R. ; Rao, L. ; Wanner, Matthew ; Raske, M. E. ; Tiller, C. ; Kimmel, R. ; Tepper, Robert. / Computed tomography score and pulmonary function in infants with chronic lung disease of infancy. In: European Respiratory Journal. 2011 ; Vol. 38, No. 4. pp. 918-923.
@article{0f4245033cbc4972920974c1c212e9e2,
title = "Computed tomography score and pulmonary function in infants with chronic lung disease of infancy",
abstract = "Chronic lung disease of infancy (CLDI) remains a common outcome among infants born extremely prematurely. In older children and adults with lung disease, pulmonary function and computed tomography (CT) scores are used to follow up respiratory disease and assess disease severity. For infants and toddlers, however, these outcomes have been used very infrequently and most often, a dichotomous respiratory outcome (presence or absence of CLDI) is employed. We evaluated the performance of CT score and pulmonary function to differentiate infants and toddlers with CLDI from a control group. CT scans, forced expiratory flows and pulmonary diffusing capacity were obtained in 39 CLDI patients and 41 controls (aged 4-33 months). CT scans were quantified using a scoring system, while pulmonary function was expressed as Z-scores. CT score outperformed pulmonary function in identifying those with CLDI. There were no significant correlations between CT score and pulmonary function. CT score had a better performance than pulmonary function in differentiating individuals with CLDI; however, these outcomes may reflect differing components of the pulmonary pathophysiology of CLDI. This new information on pulmonary outcomes can assist in designing studies with these parameters. Future studies will be required to evaluate which of the outcomes can better detect improvement with therapeutic intervention and/or lung growth. Copyright",
keywords = "Bronchopulmonary dysplasia, Forced expiratory flows, High-resolution computed tomography, Lung function, Pulmonary diffusing capacity",
author = "Sarria, {E. E.} and R. Mattiello and L. Rao and Matthew Wanner and Raske, {M. E.} and C. Tiller and R. Kimmel and Robert Tepper",
year = "2011",
month = "10",
day = "1",
doi = "10.1183/09031936.00172310",
language = "English",
volume = "38",
pages = "918--923",
journal = "European Respiratory Journal",
issn = "0903-1936",
publisher = "European Respiratory Society",
number = "4",

}

TY - JOUR

T1 - Computed tomography score and pulmonary function in infants with chronic lung disease of infancy

AU - Sarria, E. E.

AU - Mattiello, R.

AU - Rao, L.

AU - Wanner, Matthew

AU - Raske, M. E.

AU - Tiller, C.

AU - Kimmel, R.

AU - Tepper, Robert

PY - 2011/10/1

Y1 - 2011/10/1

N2 - Chronic lung disease of infancy (CLDI) remains a common outcome among infants born extremely prematurely. In older children and adults with lung disease, pulmonary function and computed tomography (CT) scores are used to follow up respiratory disease and assess disease severity. For infants and toddlers, however, these outcomes have been used very infrequently and most often, a dichotomous respiratory outcome (presence or absence of CLDI) is employed. We evaluated the performance of CT score and pulmonary function to differentiate infants and toddlers with CLDI from a control group. CT scans, forced expiratory flows and pulmonary diffusing capacity were obtained in 39 CLDI patients and 41 controls (aged 4-33 months). CT scans were quantified using a scoring system, while pulmonary function was expressed as Z-scores. CT score outperformed pulmonary function in identifying those with CLDI. There were no significant correlations between CT score and pulmonary function. CT score had a better performance than pulmonary function in differentiating individuals with CLDI; however, these outcomes may reflect differing components of the pulmonary pathophysiology of CLDI. This new information on pulmonary outcomes can assist in designing studies with these parameters. Future studies will be required to evaluate which of the outcomes can better detect improvement with therapeutic intervention and/or lung growth. Copyright

AB - Chronic lung disease of infancy (CLDI) remains a common outcome among infants born extremely prematurely. In older children and adults with lung disease, pulmonary function and computed tomography (CT) scores are used to follow up respiratory disease and assess disease severity. For infants and toddlers, however, these outcomes have been used very infrequently and most often, a dichotomous respiratory outcome (presence or absence of CLDI) is employed. We evaluated the performance of CT score and pulmonary function to differentiate infants and toddlers with CLDI from a control group. CT scans, forced expiratory flows and pulmonary diffusing capacity were obtained in 39 CLDI patients and 41 controls (aged 4-33 months). CT scans were quantified using a scoring system, while pulmonary function was expressed as Z-scores. CT score outperformed pulmonary function in identifying those with CLDI. There were no significant correlations between CT score and pulmonary function. CT score had a better performance than pulmonary function in differentiating individuals with CLDI; however, these outcomes may reflect differing components of the pulmonary pathophysiology of CLDI. This new information on pulmonary outcomes can assist in designing studies with these parameters. Future studies will be required to evaluate which of the outcomes can better detect improvement with therapeutic intervention and/or lung growth. Copyright

KW - Bronchopulmonary dysplasia

KW - Forced expiratory flows

KW - High-resolution computed tomography

KW - Lung function

KW - Pulmonary diffusing capacity

UR - http://www.scopus.com/inward/record.url?scp=80053527150&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=80053527150&partnerID=8YFLogxK

U2 - 10.1183/09031936.00172310

DO - 10.1183/09031936.00172310

M3 - Article

C2 - 21478219

AN - SCOPUS:80053527150

VL - 38

SP - 918

EP - 923

JO - European Respiratory Journal

JF - European Respiratory Journal

SN - 0903-1936

IS - 4

ER -