Computer-assisted cognitive remediation for schizophrenia: A randomized single-blind pilot study

Olga Rass, Jennifer K. Forsyth, Amanda R. Bolbecker, William P. Hetrick, Alan Breier, Paul H. Lysaker, Brian F. O'Donnell

Research output: Contribution to journalArticle

36 Scopus citations


Cognitive impairment is a core symptom in schizophrenia that has a significant impact on psychosocial function, but shows a weak response to pharmacological treatment. Consequently, a variety of cognitive remediation strategies have been evaluated to improve cognitive function in schizophrenia. The efficacy of computer-based cognitive remediation as a stand-alone intervention on general measures of neuropsychological function remains unclear. We tested the effectiveness of biweekly training using computerized cognitive remediation programs on neuropsychological and event-related potential outcome measures. Schizophrenia patients were randomly assigned to cognitive remediation training (N = 17), active control (TV-watching; N = 17), or treatment-as-usual (N = 10) groups for ten weeks and run in parallel. Cognitive and ERP measures revealed no differential improvement over time in the cognitive remediation group. Practice effects might explain change over time on several cognitive measures for all groups, consistent with studies indicating task-specific improvement. Computer-assisted cognitive remediation alone may not be sufficient for robust or generalized effects on cognitive and electrophysiological measures in schizophrenia patients.

Original languageEnglish (US)
Pages (from-to)92-98
Number of pages7
JournalSchizophrenia Research
Issue number1-3
StatePublished - Aug 1 2012


  • Auditory steady state potentials
  • Cognitive remediation
  • Cognitive training
  • Event-related potentials
  • Intervention
  • Schizophrenia

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry

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