COMT associations with disordered gambling and drinking measures

Casey R. Guillot, Jennifer R. Fanning, Tiebing Liang, Mitchell E. Berman

Research output: Contribution to journalArticle

12 Scopus citations


Disordered gambling and alcohol dependence are influenced by unique and shared genetic factors. Although the evidence is mixed, some research has linked catechol- O-methyltransferase (COMT) rs4680 (or COMT Val158Met) to the development of gambling or drinking problems; however, no molecular genetic study has jointly examined gambling and drinking problems. Furthermore, the majority of past studies examined gambling or drinking problems using a case–control design. The purpose of the current study was to examine associations of COMT rs4680 with dimensionally and categorically measured gambling and drinking problems in a nonclinical sample (139 Caucasian adults). The current study found that COMT rs4680 was related to both dimensionally and categorically measured gambling and drinking problems. It appears that the COMT Met/Met genotype may be a genetic risk factor that contributes to the development of both gambling and drinking problems.

Original languageEnglish (US)
Article numberA011
Pages (from-to)513-524
Number of pages12
JournalJournal of Gambling Studies
Issue number2
StatePublished - Jan 4 2014



  • Alcohol use
  • COMT gene
  • Gambling
  • Michigan Alcoholism Screening Test
  • South Oaks Gambling Screen

ASJC Scopus subject areas

  • Sociology and Political Science
  • Psychology(all)

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