Concise review: Role of DEK in stem/progenitor cell biology

Hal Broxmeyer, Nirit Mor-Vaknin, Ferdinand Kappes, Maureen Legendre, Anjan K. Saha, Xuan Ou, Heather O'leary, Maegan Capitano, Scott Cooper, David M. Markovitz

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Understanding the factors that regulate hematopoiesis opens up the possibility of modifying these factors and their actions for clinical benefit. DEK, a non-histone nuclear phosphoprotein initially identified as a putative proto-oncogene, has recently been linked to regulate hematopoiesis. DEK has myelosuppressive activity in vitro on proliferation of human and mouse hematopoietic progenitor cells and enhancing activity on engraftment of longterm marrow repopulating mouse stem cells, has been linked in coordinate regulation with the transcription factor C/EBPα, for differentiation of myeloid cells, and apparently targets a long-term repopulating hematopoietic stem cell for leukemic transformation. This review covers the uniqueness of DEK, what is known about how it now functions as a nuclear protein and also as a secreted molecule that can act in paracrine fashion, and how it may be regulated in part by dipeptidylpeptidase 4, an enzyme known to truncate and modify a number of proteins involved in activities on hematopoietic cells. Examples are provided of possible future areas of investigation needed to better understand how DEK may be regulated and function as a regulator of hematopoiesis, information possibly translatable to other normal and diseased immature cell systems.

Original languageEnglish
Pages (from-to)1447-1453
Number of pages7
JournalStem Cells
Volume31
Issue number8
DOIs
StatePublished - Aug 2013

Fingerprint

Hematopoiesis
Cell Biology
Stem Cells
Hematopoietic Stem Cells
Proto-Oncogenes
Phosphoproteins
Myeloid Cells
Nuclear Proteins
Transcription Factors
Bone Marrow
Enzymes
Proteins

Keywords

  • Chromatin
  • DEK
  • Dipeptidylpeptidase IV
  • Hematopoietic progenitor cells
  • Hematopoietic stem cells
  • Receptors

ASJC Scopus subject areas

  • Cell Biology
  • Developmental Biology
  • Molecular Medicine

Cite this

Broxmeyer, H., Mor-Vaknin, N., Kappes, F., Legendre, M., Saha, A. K., Ou, X., ... Markovitz, D. M. (2013). Concise review: Role of DEK in stem/progenitor cell biology. Stem Cells, 31(8), 1447-1453. https://doi.org/10.1002/stem.1443

Concise review : Role of DEK in stem/progenitor cell biology. / Broxmeyer, Hal; Mor-Vaknin, Nirit; Kappes, Ferdinand; Legendre, Maureen; Saha, Anjan K.; Ou, Xuan; O'leary, Heather; Capitano, Maegan; Cooper, Scott; Markovitz, David M.

In: Stem Cells, Vol. 31, No. 8, 08.2013, p. 1447-1453.

Research output: Contribution to journalArticle

Broxmeyer, H, Mor-Vaknin, N, Kappes, F, Legendre, M, Saha, AK, Ou, X, O'leary, H, Capitano, M, Cooper, S & Markovitz, DM 2013, 'Concise review: Role of DEK in stem/progenitor cell biology', Stem Cells, vol. 31, no. 8, pp. 1447-1453. https://doi.org/10.1002/stem.1443
Broxmeyer H, Mor-Vaknin N, Kappes F, Legendre M, Saha AK, Ou X et al. Concise review: Role of DEK in stem/progenitor cell biology. Stem Cells. 2013 Aug;31(8):1447-1453. https://doi.org/10.1002/stem.1443
Broxmeyer, Hal ; Mor-Vaknin, Nirit ; Kappes, Ferdinand ; Legendre, Maureen ; Saha, Anjan K. ; Ou, Xuan ; O'leary, Heather ; Capitano, Maegan ; Cooper, Scott ; Markovitz, David M. / Concise review : Role of DEK in stem/progenitor cell biology. In: Stem Cells. 2013 ; Vol. 31, No. 8. pp. 1447-1453.
@article{d569fdb5a6594e3aaccdb1629f99365f,
title = "Concise review: Role of DEK in stem/progenitor cell biology",
abstract = "Understanding the factors that regulate hematopoiesis opens up the possibility of modifying these factors and their actions for clinical benefit. DEK, a non-histone nuclear phosphoprotein initially identified as a putative proto-oncogene, has recently been linked to regulate hematopoiesis. DEK has myelosuppressive activity in vitro on proliferation of human and mouse hematopoietic progenitor cells and enhancing activity on engraftment of longterm marrow repopulating mouse stem cells, has been linked in coordinate regulation with the transcription factor C/EBPα, for differentiation of myeloid cells, and apparently targets a long-term repopulating hematopoietic stem cell for leukemic transformation. This review covers the uniqueness of DEK, what is known about how it now functions as a nuclear protein and also as a secreted molecule that can act in paracrine fashion, and how it may be regulated in part by dipeptidylpeptidase 4, an enzyme known to truncate and modify a number of proteins involved in activities on hematopoietic cells. Examples are provided of possible future areas of investigation needed to better understand how DEK may be regulated and function as a regulator of hematopoiesis, information possibly translatable to other normal and diseased immature cell systems.",
keywords = "Chromatin, DEK, Dipeptidylpeptidase IV, Hematopoietic progenitor cells, Hematopoietic stem cells, Receptors",
author = "Hal Broxmeyer and Nirit Mor-Vaknin and Ferdinand Kappes and Maureen Legendre and Saha, {Anjan K.} and Xuan Ou and Heather O'leary and Maegan Capitano and Scott Cooper and Markovitz, {David M.}",
year = "2013",
month = "8",
doi = "10.1002/stem.1443",
language = "English",
volume = "31",
pages = "1447--1453",
journal = "Stem Cells",
issn = "1066-5099",
publisher = "AlphaMed Press",
number = "8",

}

TY - JOUR

T1 - Concise review

T2 - Role of DEK in stem/progenitor cell biology

AU - Broxmeyer, Hal

AU - Mor-Vaknin, Nirit

AU - Kappes, Ferdinand

AU - Legendre, Maureen

AU - Saha, Anjan K.

AU - Ou, Xuan

AU - O'leary, Heather

AU - Capitano, Maegan

AU - Cooper, Scott

AU - Markovitz, David M.

PY - 2013/8

Y1 - 2013/8

N2 - Understanding the factors that regulate hematopoiesis opens up the possibility of modifying these factors and their actions for clinical benefit. DEK, a non-histone nuclear phosphoprotein initially identified as a putative proto-oncogene, has recently been linked to regulate hematopoiesis. DEK has myelosuppressive activity in vitro on proliferation of human and mouse hematopoietic progenitor cells and enhancing activity on engraftment of longterm marrow repopulating mouse stem cells, has been linked in coordinate regulation with the transcription factor C/EBPα, for differentiation of myeloid cells, and apparently targets a long-term repopulating hematopoietic stem cell for leukemic transformation. This review covers the uniqueness of DEK, what is known about how it now functions as a nuclear protein and also as a secreted molecule that can act in paracrine fashion, and how it may be regulated in part by dipeptidylpeptidase 4, an enzyme known to truncate and modify a number of proteins involved in activities on hematopoietic cells. Examples are provided of possible future areas of investigation needed to better understand how DEK may be regulated and function as a regulator of hematopoiesis, information possibly translatable to other normal and diseased immature cell systems.

AB - Understanding the factors that regulate hematopoiesis opens up the possibility of modifying these factors and their actions for clinical benefit. DEK, a non-histone nuclear phosphoprotein initially identified as a putative proto-oncogene, has recently been linked to regulate hematopoiesis. DEK has myelosuppressive activity in vitro on proliferation of human and mouse hematopoietic progenitor cells and enhancing activity on engraftment of longterm marrow repopulating mouse stem cells, has been linked in coordinate regulation with the transcription factor C/EBPα, for differentiation of myeloid cells, and apparently targets a long-term repopulating hematopoietic stem cell for leukemic transformation. This review covers the uniqueness of DEK, what is known about how it now functions as a nuclear protein and also as a secreted molecule that can act in paracrine fashion, and how it may be regulated in part by dipeptidylpeptidase 4, an enzyme known to truncate and modify a number of proteins involved in activities on hematopoietic cells. Examples are provided of possible future areas of investigation needed to better understand how DEK may be regulated and function as a regulator of hematopoiesis, information possibly translatable to other normal and diseased immature cell systems.

KW - Chromatin

KW - DEK

KW - Dipeptidylpeptidase IV

KW - Hematopoietic progenitor cells

KW - Hematopoietic stem cells

KW - Receptors

UR - http://www.scopus.com/inward/record.url?scp=84883379108&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84883379108&partnerID=8YFLogxK

U2 - 10.1002/stem.1443

DO - 10.1002/stem.1443

M3 - Article

C2 - 23733396

AN - SCOPUS:84883379108

VL - 31

SP - 1447

EP - 1453

JO - Stem Cells

JF - Stem Cells

SN - 1066-5099

IS - 8

ER -