Concise Review: Sowing the seeds of a fruitful harvest: Hematopoietic stem cell mobilization

Jonathan Hoggatt, Jennifer M. Speth, Louis M. Pelus

Research output: Contribution to journalArticle

19 Scopus citations

Abstract

Hematopoietic stem cell transplantation is the only curative option for a number of malignant and nonmalignant diseases. As the use of hematopoietic transplant has expanded, so too has the source of stem and progenitor cells. The predominate source of stem and progenitors today, particularly in settings of autologous transplantation, is mobilized peripheral blood. This review will highlight the historical advances which led to the widespread use of peripheral blood stem cells for transplantation, with a look toward future enhancements to mobilization strategies.

Original languageEnglish (US)
Pages (from-to)2599-2606
Number of pages8
JournalSTEM CELLS
Volume31
Issue number12
DOIs
StatePublished - Dec 1 2013

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Keywords

  • AMD3100 (plerixafor)
  • CXCR4
  • Granulocyte-colony stimulating factor
  • Hematopoietic stem cell
  • Mobilization
  • Stem cell niche

ASJC Scopus subject areas

  • Cell Biology
  • Developmental Biology
  • Molecular Medicine

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