Concurrent angiomyolipoma and renal cell neoplasia

A study of 36 cases

Rafael E. Jimenez, John Eble, Victor E. Reuter, Jonathan I. Epstein, Andrew L. Folpe, Mariza De Peralta-Venturina, Pheroze Tamboli, I. David Ansell, David Grignon, Robert H. Young, Mahul B. Amin

Research output: Contribution to journalArticle

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Abstract

Little is known about the association of angiomyolipoma and adult renal-cell neoplasia. We studied the clinicopathologic features of 36 patients with concurrent angiomyolipoma and renal-cell neoplasia from the consultation and surgical pathology files of nine institutions. HMB-45 immunoreactivity was analyzed in both neoplasms. Twenty-five sporadic cases of patients with angiomyolipoma and renal-cell neoplasia and 11 cases of patients with tuberous sclerosis, as defined by Gomez' criteria, had mean ages of 59 and 53 years, respectively, and female-male ratios of 2:1 and 5:1, respectively. The mean size of the angiomyolipomas was 1 cm in the sporadic cases and 3 cm in those patients with tuberous sclerosis (medians: 0.5 and 3 cm, respectively, P = .002). The mean sizes of the renal-cell neoplasms were 5 cm in sporadic cases and 6 cm in patients with tuberous sclerosis (medians: 4 and 5 cm, respectively; P = .88). In both clinical settings, angiomyolipoma was more commonly the incidental tumor. Clear-cell (conventional) renal-cell carcinoma was the most common renal-cell neoplasm in both groups of patients, accounting for approximately two thirds of the rumors. In patients with tuberous sclerosis, 27% of renal-cell neoplasms were oncocytomas, compared with 8% in sporadic cases (P = .15). Papillary neoplasia, chromophobe, and collecting-duct renal-cell carcinoma were found only in sporadic cases. All of the 22 renal-cell neoplasms studied were negative for HMB-45, whereas all 25 angiomyolipomas studied were positive.

Original languageEnglish
Pages (from-to)157-163
Number of pages7
JournalModern Pathology
Volume14
Issue number3
DOIs
StatePublished - 2001

Fingerprint

Angiomyolipoma
Tuberous Sclerosis
Kidney
Kidney Neoplasms
Renal Cell Carcinoma
Neoplasms
Oxyphilic Adenoma
Surgical Pathology
Cell Size
Referral and Consultation

Keywords

  • Angiomyolipoma
  • Clear cell carcinoma
  • Collision neoplasms
  • Kidney
  • Oncocytoma
  • Renal cell carcinoma
  • Renal cell neoplasia

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Jimenez, R. E., Eble, J., Reuter, V. E., Epstein, J. I., Folpe, A. L., De Peralta-Venturina, M., ... Amin, M. B. (2001). Concurrent angiomyolipoma and renal cell neoplasia: A study of 36 cases. Modern Pathology, 14(3), 157-163. https://doi.org/10.1038/modpathol.3880275

Concurrent angiomyolipoma and renal cell neoplasia : A study of 36 cases. / Jimenez, Rafael E.; Eble, John; Reuter, Victor E.; Epstein, Jonathan I.; Folpe, Andrew L.; De Peralta-Venturina, Mariza; Tamboli, Pheroze; Ansell, I. David; Grignon, David; Young, Robert H.; Amin, Mahul B.

In: Modern Pathology, Vol. 14, No. 3, 2001, p. 157-163.

Research output: Contribution to journalArticle

Jimenez, RE, Eble, J, Reuter, VE, Epstein, JI, Folpe, AL, De Peralta-Venturina, M, Tamboli, P, Ansell, ID, Grignon, D, Young, RH & Amin, MB 2001, 'Concurrent angiomyolipoma and renal cell neoplasia: A study of 36 cases', Modern Pathology, vol. 14, no. 3, pp. 157-163. https://doi.org/10.1038/modpathol.3880275
Jimenez RE, Eble J, Reuter VE, Epstein JI, Folpe AL, De Peralta-Venturina M et al. Concurrent angiomyolipoma and renal cell neoplasia: A study of 36 cases. Modern Pathology. 2001;14(3):157-163. https://doi.org/10.1038/modpathol.3880275
Jimenez, Rafael E. ; Eble, John ; Reuter, Victor E. ; Epstein, Jonathan I. ; Folpe, Andrew L. ; De Peralta-Venturina, Mariza ; Tamboli, Pheroze ; Ansell, I. David ; Grignon, David ; Young, Robert H. ; Amin, Mahul B. / Concurrent angiomyolipoma and renal cell neoplasia : A study of 36 cases. In: Modern Pathology. 2001 ; Vol. 14, No. 3. pp. 157-163.
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