Conditional knock-out of β-catenin in postnatal-born dentate gyrus granule neurons results in dendritic malformation

Xiang Gao, Paola Arlotta, Jeffrey D. Macklis, Jinhui Chen

Research output: Contribution to journalArticle

64 Citations (Scopus)

Abstract

Neurons are continuously added to the brain throughout life, and these neurons must develop dendritic arbors and functional connections with existing neurons to be integrated into neuronal circuitry. The molecular mechanisms that regulate dendritic development of newborn neurons in the hippocampal dentate gyrus are still unclear. Here, we show that β-catenin is expressed in newborn granule neurons and in neural progenitor cells in the hippocampal dentate gyrus. Specific knock-out of β-catenin in newborn neurons, without affecting β-catenin expression in neural progenitor cells, led to defects in dendritic morphology of these newborn neurons in vivo. Majority of newborn neurons that cannot extend dendrites survive

Original languageEnglish (US)
Pages (from-to)14317-14325
Number of pages9
JournalJournal of Neuroscience
Volume27
Issue number52
DOIs
StatePublished - Dec 26 2007
Externally publishedYes

Fingerprint

Catenins
Dentate Gyrus
Neurons
Parahippocampal Gyrus
Stem Cells
Dendrites
Brain

Keywords

  • β-catenin
  • Conditional knock-out
  • Dendritic development
  • Dentate gyrus granule neurons
  • Hippocampus
  • Newborns

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Conditional knock-out of β-catenin in postnatal-born dentate gyrus granule neurons results in dendritic malformation. / Gao, Xiang; Arlotta, Paola; Macklis, Jeffrey D.; Chen, Jinhui.

In: Journal of Neuroscience, Vol. 27, No. 52, 26.12.2007, p. 14317-14325.

Research output: Contribution to journalArticle

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