Conditional knock-out of β-catenin in postnatal-born dentate gyrus granule neurons results in dendritic malformation

Xiang Gao, Paola Arlotta, Jeffrey D. Macklis, Jinhui Chen

Research output: Contribution to journalArticle

71 Scopus citations

Abstract

Neurons are continuously added to the brain throughout life, and these neurons must develop dendritic arbors and functional connections with existing neurons to be integrated into neuronal circuitry. The molecular mechanisms that regulate dendritic development of newborn neurons in the hippocampal dentate gyrus are still unclear. Here, we show that β-catenin is expressed in newborn granule neurons and in neural progenitor cells in the hippocampal dentate gyrus. Specific knock-out of β-catenin in newborn neurons, without affecting β-catenin expression in neural progenitor cells, led to defects in dendritic morphology of these newborn neurons in vivo. Majority of newborn neurons that cannot extend dendrites survive <1 month after they were born. Our results indicate that β-catenin plays an important role in dendritic development of postnatal-born neurons in vivo,andis therefore essential for the neurogenesis in the postnatal brain.

Original languageEnglish (US)
Pages (from-to)14317-14325
Number of pages9
JournalJournal of Neuroscience
Volume27
Issue number52
DOIs
StatePublished - Dec 26 2007

Keywords

  • Conditional knock-out
  • Dendritic development
  • Dentate gyrus granule neurons
  • Hippocampus
  • Newborns
  • β-catenin

ASJC Scopus subject areas

  • Neuroscience(all)

Fingerprint Dive into the research topics of 'Conditional knock-out of β-catenin in postnatal-born dentate gyrus granule neurons results in dendritic malformation'. Together they form a unique fingerprint.

  • Cite this