Conditioning of cyclophosphamide-induced leukopenia in humans

Daniel W. Giang, Andrew D. Goodman, Randolph B. Schiffer, David Mattson, Mary Petrie, Nicholas Cohen, Robert Ader

Research output: Contribution to journalArticle

70 Citations (Scopus)

Abstract

This study evaluated whether decrements in peripheral leukocyte counts induced by cyclophosphamide can be conditioned in humans. Ten subjects being treated for multiple sclerosis received four intravenous treatments with cyclophosphamide (unconditioned stimulus) paired with a conditioned stimulus. Subjects received conditioned stimulus plus 20 mg of cyclophosphamide during one of the next two treatments in a double-blind manner. Eight of 10 subjects (P = 0.044) displayed decreased peripheral leukocyte counts following conditioned stimulus. This change may have resulted from classical conditioning processes.

Original languageEnglish (US)
Pages (from-to)194-201
Number of pages8
JournalJournal of Neuropsychiatry and Clinical Neurosciences
Volume8
Issue number2
StatePublished - Mar 1996
Externally publishedYes

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Leukopenia
Cyclophosphamide
Leukocyte Count
Classical Conditioning
Multiple Sclerosis
Conditioning (Psychology)

ASJC Scopus subject areas

  • Neuropsychology and Physiological Psychology
  • Neuroscience(all)

Cite this

Giang, D. W., Goodman, A. D., Schiffer, R. B., Mattson, D., Petrie, M., Cohen, N., & Ader, R. (1996). Conditioning of cyclophosphamide-induced leukopenia in humans. Journal of Neuropsychiatry and Clinical Neurosciences, 8(2), 194-201.

Conditioning of cyclophosphamide-induced leukopenia in humans. / Giang, Daniel W.; Goodman, Andrew D.; Schiffer, Randolph B.; Mattson, David; Petrie, Mary; Cohen, Nicholas; Ader, Robert.

In: Journal of Neuropsychiatry and Clinical Neurosciences, Vol. 8, No. 2, 03.1996, p. 194-201.

Research output: Contribution to journalArticle

Giang, DW, Goodman, AD, Schiffer, RB, Mattson, D, Petrie, M, Cohen, N & Ader, R 1996, 'Conditioning of cyclophosphamide-induced leukopenia in humans', Journal of Neuropsychiatry and Clinical Neurosciences, vol. 8, no. 2, pp. 194-201.
Giang DW, Goodman AD, Schiffer RB, Mattson D, Petrie M, Cohen N et al. Conditioning of cyclophosphamide-induced leukopenia in humans. Journal of Neuropsychiatry and Clinical Neurosciences. 1996 Mar;8(2):194-201.
Giang, Daniel W. ; Goodman, Andrew D. ; Schiffer, Randolph B. ; Mattson, David ; Petrie, Mary ; Cohen, Nicholas ; Ader, Robert. / Conditioning of cyclophosphamide-induced leukopenia in humans. In: Journal of Neuropsychiatry and Clinical Neurosciences. 1996 ; Vol. 8, No. 2. pp. 194-201.
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