Conditioning of cyclophosphamide-induced leukopenia in humans

Daniel W. Giang, Andrew D. Goodman, Randolph B. Schiffer, David H. Mattson, Mary Petrie, Nicholas Cohen, Robert Ader

Research output: Contribution to journalArticle

77 Scopus citations


This study evaluated whether decrements in peripheral leukocyte counts induced by cyclophosphamide can be conditioned in humans. Ten subjects being treated for multiple sclerosis received four intravenous treatments with cyclophosphamide (unconditioned stimulus) paired with a conditioned stimulus. Subjects received conditioned stimulus plus 20 mg of cyclophosphamide during one of the next two treatments in a double-blind manner. Eight of 10 subjects (P = 0.044) displayed decreased peripheral leukocyte counts following conditioned stimulus. This change may have resulted from classical conditioning processes.

Original languageEnglish (US)
Pages (from-to)194-201
Number of pages8
JournalJournal of Neuropsychiatry and Clinical Neurosciences
Issue number2
StatePublished - Jan 1 1996
Externally publishedYes

ASJC Scopus subject areas

  • Clinical Neurology
  • Psychiatry and Mental health

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