Conductance sizing balloon for measurement of peripheral artery minimal stent area

Mark C. Svendsen, A. George Akingba, Anjan Sinha, Brooke Chattin, Amelia Turner, Margaret Brass, Deepak L. Bhatt, Ghassan S. Kassab

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Background: Because stent underdeployment occurs frequently, accurate minimal stent area (MSA) measurement during postdilatation is necessary. This study investigated the accuracy and repeatability for MSA determination using a novel conductance balloon (CB) catheter for peripheral vessels. Methods: The CB catheter is a standard balloon catheter that measures electrical conductance (ratio of current/voltage drop) in real-time during inflation, which directly relates to the balloon cross-sectional area through Ohm's law. CB measurements were made in 4- to 10-mm phantoms on the bench, ex vivo in stents fully deployed in diseased human peripheral arteries, and in vivo in stents fully deployed in peripheral vessels in six swine. CB measurement accuracy and repeatability were calculated and compared with the known dimension (bench phantoms) or with intravascular ultrasound (IVUS) measurement after stent deployment (ex vivo and in vivo). Results: CB measurements were highly accurate (error: 1.8% bench, 5% ex vivo, and 5% in vivo) and repeatable (error: 0.9% bench, 1.8% ex vivo, and 1.3% in vivo), with virtually no bias (average difference in measurements: -0.05 mm bench CB vs known phantom diameters, -0.06 mm ex vivo CB vs IVUS, and -0.11 mm in vivo CB vs IVUS). Conclusions: The CB sizing capability can be integrated within a standard balloon catheter (two-in-one function) to provide accurate, real-time assessment of MSA to ensure full stent apposition rather than the use of pressure as a surrogate for size.

Original languageEnglish (US)
Pages (from-to)759-766
Number of pages8
JournalJournal of Vascular Surgery
Volume60
Issue number3
DOIs
StatePublished - 2014

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Stents
Arteries
Catheters
Peripheral Arterial Disease
Economic Inflation
Swine
Pressure

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Surgery

Cite this

Svendsen, M. C., Akingba, A. G., Sinha, A., Chattin, B., Turner, A., Brass, M., ... Kassab, G. S. (2014). Conductance sizing balloon for measurement of peripheral artery minimal stent area. Journal of Vascular Surgery, 60(3), 759-766. https://doi.org/10.1016/j.jvs.2013.06.095

Conductance sizing balloon for measurement of peripheral artery minimal stent area. / Svendsen, Mark C.; Akingba, A. George; Sinha, Anjan; Chattin, Brooke; Turner, Amelia; Brass, Margaret; Bhatt, Deepak L.; Kassab, Ghassan S.

In: Journal of Vascular Surgery, Vol. 60, No. 3, 2014, p. 759-766.

Research output: Contribution to journalArticle

Svendsen, MC, Akingba, AG, Sinha, A, Chattin, B, Turner, A, Brass, M, Bhatt, DL & Kassab, GS 2014, 'Conductance sizing balloon for measurement of peripheral artery minimal stent area', Journal of Vascular Surgery, vol. 60, no. 3, pp. 759-766. https://doi.org/10.1016/j.jvs.2013.06.095
Svendsen, Mark C. ; Akingba, A. George ; Sinha, Anjan ; Chattin, Brooke ; Turner, Amelia ; Brass, Margaret ; Bhatt, Deepak L. ; Kassab, Ghassan S. / Conductance sizing balloon for measurement of peripheral artery minimal stent area. In: Journal of Vascular Surgery. 2014 ; Vol. 60, No. 3. pp. 759-766.
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AU - Sinha, Anjan

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AU - Brass, Margaret

AU - Bhatt, Deepak L.

AU - Kassab, Ghassan S.

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N2 - Background: Because stent underdeployment occurs frequently, accurate minimal stent area (MSA) measurement during postdilatation is necessary. This study investigated the accuracy and repeatability for MSA determination using a novel conductance balloon (CB) catheter for peripheral vessels. Methods: The CB catheter is a standard balloon catheter that measures electrical conductance (ratio of current/voltage drop) in real-time during inflation, which directly relates to the balloon cross-sectional area through Ohm's law. CB measurements were made in 4- to 10-mm phantoms on the bench, ex vivo in stents fully deployed in diseased human peripheral arteries, and in vivo in stents fully deployed in peripheral vessels in six swine. CB measurement accuracy and repeatability were calculated and compared with the known dimension (bench phantoms) or with intravascular ultrasound (IVUS) measurement after stent deployment (ex vivo and in vivo). Results: CB measurements were highly accurate (error: 1.8% bench, 5% ex vivo, and 5% in vivo) and repeatable (error: 0.9% bench, 1.8% ex vivo, and 1.3% in vivo), with virtually no bias (average difference in measurements: -0.05 mm bench CB vs known phantom diameters, -0.06 mm ex vivo CB vs IVUS, and -0.11 mm in vivo CB vs IVUS). Conclusions: The CB sizing capability can be integrated within a standard balloon catheter (two-in-one function) to provide accurate, real-time assessment of MSA to ensure full stent apposition rather than the use of pressure as a surrogate for size.

AB - Background: Because stent underdeployment occurs frequently, accurate minimal stent area (MSA) measurement during postdilatation is necessary. This study investigated the accuracy and repeatability for MSA determination using a novel conductance balloon (CB) catheter for peripheral vessels. Methods: The CB catheter is a standard balloon catheter that measures electrical conductance (ratio of current/voltage drop) in real-time during inflation, which directly relates to the balloon cross-sectional area through Ohm's law. CB measurements were made in 4- to 10-mm phantoms on the bench, ex vivo in stents fully deployed in diseased human peripheral arteries, and in vivo in stents fully deployed in peripheral vessels in six swine. CB measurement accuracy and repeatability were calculated and compared with the known dimension (bench phantoms) or with intravascular ultrasound (IVUS) measurement after stent deployment (ex vivo and in vivo). Results: CB measurements were highly accurate (error: 1.8% bench, 5% ex vivo, and 5% in vivo) and repeatable (error: 0.9% bench, 1.8% ex vivo, and 1.3% in vivo), with virtually no bias (average difference in measurements: -0.05 mm bench CB vs known phantom diameters, -0.06 mm ex vivo CB vs IVUS, and -0.11 mm in vivo CB vs IVUS). Conclusions: The CB sizing capability can be integrated within a standard balloon catheter (two-in-one function) to provide accurate, real-time assessment of MSA to ensure full stent apposition rather than the use of pressure as a surrogate for size.

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