Confirmation of subtle motor changes among presymptomatic carriers of the huntington disease gene

Sandra Close Kirhwood, Eric Siemers, Cherie Bond, P. Michael Comically, Joe C. Christian, Tatiana Foroud

Research output: Contribution to journalArticle

62 Citations (Scopus)

Abstract

Objective: To confirm that subtle changes in motor function and reaction time are present in presymptomatic individuals carrying the expanded Huntington disease (HD) allele. Design: A case-control, double-blind study comparing presymptomatic HD gene carriers (PSGCs) and non-gene carriers (NGCs) at risk for HD. Setting: The Department of Medical and Molecular Genetics at a general clinical research center in a midwestern city. Participants: Two hundred sixteen individuals at risk for HD who were asymptomatic by self-report and who did not have manifest HD on results of clinical examination, including PSGCs (n=61) and NGCs (n=155). Measures: Molecular testing was used to determine the number of CAG repeats in the HDgene. A quantified neurologic examination and a battery of physiological measures of central nervous system function measuring speed of movement and reaction time were administered. Results: On neurologic examination, the PSGCs exhibited significantly more definite or possible abnormalities than NGCs for overall oculomotor function, saccade velocity, optokinetic nystagmus, chorea of the extremities, and dystonia of the extremities (P<.05). The PSGCs also had significantly slower performance for auditory reaction time, visual reaction time, visual reaction time with decision, movement time, movement time with decision, and button-tapping time, compared with the NGCs (P<.05). Conclusions: Subtle changes in motor function, speed of movement, and reaction time are present in HD gene carriers who do not exhibit definite choreiform movements and who do not have sufficient signs to make a clinical diagnosis of HD. In addition, a trend toward slower speed of movement and reaction time was observed among this population as their neurologic abnormalities increased.

Original languageEnglish
Pages (from-to)1040-1044
Number of pages5
JournalArchives of Neurology
Volume57
Issue number7
StatePublished - Jul 2000

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Huntington Disease
Reaction Time
Genes
Chorea
Neurologic Examination
Extremities
Optokinetic Nystagmus
Nervous System Malformations
Asymptomatic Diseases
Dystonia
Saccades
Medical Genetics
Gene
Carrier
Double-Blind Method
Self Report
Molecular Biology
Central Nervous System
Alleles
Research

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Kirhwood, S. C., Siemers, E., Bond, C., Comically, P. M., Christian, J. C., & Foroud, T. (2000). Confirmation of subtle motor changes among presymptomatic carriers of the huntington disease gene. Archives of Neurology, 57(7), 1040-1044.

Confirmation of subtle motor changes among presymptomatic carriers of the huntington disease gene. / Kirhwood, Sandra Close; Siemers, Eric; Bond, Cherie; Comically, P. Michael; Christian, Joe C.; Foroud, Tatiana.

In: Archives of Neurology, Vol. 57, No. 7, 07.2000, p. 1040-1044.

Research output: Contribution to journalArticle

Kirhwood, SC, Siemers, E, Bond, C, Comically, PM, Christian, JC & Foroud, T 2000, 'Confirmation of subtle motor changes among presymptomatic carriers of the huntington disease gene', Archives of Neurology, vol. 57, no. 7, pp. 1040-1044.
Kirhwood SC, Siemers E, Bond C, Comically PM, Christian JC, Foroud T. Confirmation of subtle motor changes among presymptomatic carriers of the huntington disease gene. Archives of Neurology. 2000 Jul;57(7):1040-1044.
Kirhwood, Sandra Close ; Siemers, Eric ; Bond, Cherie ; Comically, P. Michael ; Christian, Joe C. ; Foroud, Tatiana. / Confirmation of subtle motor changes among presymptomatic carriers of the huntington disease gene. In: Archives of Neurology. 2000 ; Vol. 57, No. 7. pp. 1040-1044.
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