Conformal mixed neutron and photon irradiation in localized and locally advanced prostate cancer: Preliminary estimates of the therapeutic ratio

Jeffrey D. Forman, Marie Duclos, Renu Sharma, Paul Chuba, Kim Hart, Mark Yudelev, Syamala Devi, Wayne Court, Falah Shamsa, Peter Littrup, David Grignon, Arthur Porter, Richard Maughan

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

Purpose: To determine the incidence of chronic toxicity and the probability of biochemical and histologic complete response among patients with nonmetastatic prostate cancer, treated with three dimensional (3D) conformal mixed neutron and photon irradiation. Methods and Materials: Between November 1991 and December 1994, 151 patients with prostate cancer were entered in three prospective dose-finding studies of conformal mixed neutron and photon irradiation. Patients with low stage, low to intermediate grade prostate cancer (T1-2NXM0, Gleason Score ≤7) received 38 Photon Gy (PhGy) plus 9 (51 patients) or 10 (53 patients) Neutron Gy (NGy) to the prostate and seminal vesicles. Forty-seven patients with locally advanced prostate cancer (T3-4 N0-1 M0 and/or Gleason Score ≥8) received 15 NGy + 18 PhGy to the prostate and seminal vesicles and 9 NGy + 18 PhGy to the pelvic lymph nodes. Results: The median follow-up was 16 months (range: 3-30 months). There was no Grade 3-5 GI or GU toxicity recorded. At 20 months, the actuarial rates of Grade 2 GI morbidity were 6 and 29% for the 910 and 15 NGy protocols, respectively (p = 0.07). At 20 months, the incidences of Grade 2 GU morbidity were 4 and 16%, respectively (p = 0.08). Stiffness in flexing or abducting the hips was seen in 20 and 42% of patients receiving 9-10 and 15 NGy, respectively (p = 0.01). Potency was maintained in 65% of all patients. Among patients with an initial PSA ≤10, 100% had a 12-month PSA

Original languageEnglish (US)
Pages (from-to)259-266
Number of pages8
JournalInternational Journal of Radiation Oncology Biology Physics
Volume35
Issue number2
DOIs
StatePublished - May 1 1996
Externally publishedYes

Fingerprint

Neutrons
neutron irradiation
Photons
Prostatic Neoplasms
cancer
irradiation
photons
estimates
grade
neutrons
Therapeutics
Neoplasm Grading
Seminal Vesicles
toxicity
Prostate
incidence
Morbidity
lymphatic system
flexing
Incidence

Keywords

  • Conformal neutron irradiation
  • Prostate cancer

ASJC Scopus subject areas

  • Oncology
  • Radiology Nuclear Medicine and imaging
  • Radiation

Cite this

Conformal mixed neutron and photon irradiation in localized and locally advanced prostate cancer : Preliminary estimates of the therapeutic ratio. / Forman, Jeffrey D.; Duclos, Marie; Sharma, Renu; Chuba, Paul; Hart, Kim; Yudelev, Mark; Devi, Syamala; Court, Wayne; Shamsa, Falah; Littrup, Peter; Grignon, David; Porter, Arthur; Maughan, Richard.

In: International Journal of Radiation Oncology Biology Physics, Vol. 35, No. 2, 01.05.1996, p. 259-266.

Research output: Contribution to journalArticle

Forman, Jeffrey D. ; Duclos, Marie ; Sharma, Renu ; Chuba, Paul ; Hart, Kim ; Yudelev, Mark ; Devi, Syamala ; Court, Wayne ; Shamsa, Falah ; Littrup, Peter ; Grignon, David ; Porter, Arthur ; Maughan, Richard. / Conformal mixed neutron and photon irradiation in localized and locally advanced prostate cancer : Preliminary estimates of the therapeutic ratio. In: International Journal of Radiation Oncology Biology Physics. 1996 ; Vol. 35, No. 2. pp. 259-266.
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T1 - Conformal mixed neutron and photon irradiation in localized and locally advanced prostate cancer

T2 - Preliminary estimates of the therapeutic ratio

AU - Forman, Jeffrey D.

AU - Duclos, Marie

AU - Sharma, Renu

AU - Chuba, Paul

AU - Hart, Kim

AU - Yudelev, Mark

AU - Devi, Syamala

AU - Court, Wayne

AU - Shamsa, Falah

AU - Littrup, Peter

AU - Grignon, David

AU - Porter, Arthur

AU - Maughan, Richard

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N2 - Purpose: To determine the incidence of chronic toxicity and the probability of biochemical and histologic complete response among patients with nonmetastatic prostate cancer, treated with three dimensional (3D) conformal mixed neutron and photon irradiation. Methods and Materials: Between November 1991 and December 1994, 151 patients with prostate cancer were entered in three prospective dose-finding studies of conformal mixed neutron and photon irradiation. Patients with low stage, low to intermediate grade prostate cancer (T1-2NXM0, Gleason Score ≤7) received 38 Photon Gy (PhGy) plus 9 (51 patients) or 10 (53 patients) Neutron Gy (NGy) to the prostate and seminal vesicles. Forty-seven patients with locally advanced prostate cancer (T3-4 N0-1 M0 and/or Gleason Score ≥8) received 15 NGy + 18 PhGy to the prostate and seminal vesicles and 9 NGy + 18 PhGy to the pelvic lymph nodes. Results: The median follow-up was 16 months (range: 3-30 months). There was no Grade 3-5 GI or GU toxicity recorded. At 20 months, the actuarial rates of Grade 2 GI morbidity were 6 and 29% for the 910 and 15 NGy protocols, respectively (p = 0.07). At 20 months, the incidences of Grade 2 GU morbidity were 4 and 16%, respectively (p = 0.08). Stiffness in flexing or abducting the hips was seen in 20 and 42% of patients receiving 9-10 and 15 NGy, respectively (p = 0.01). Potency was maintained in 65% of all patients. Among patients with an initial PSA ≤10, 100% had a 12-month PSA

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