Connect MM Registry as a national reference for United States multiple myeloma patients

on behalf of Connect MM Registry Investigators

Research output: Contribution to journalArticle

Abstract

Background: The Surveillance, Epidemiology, and End Results (SEER) database and National Cancer Database (NCDB) show improved overall survival (OS) in patients with multiple myeloma (MM) over the last 15 years. This analysis evaluated the validity of the largely community-based Connect MM Registry as a national reference for MM. Methods: Baseline disease characteristics and survival in US newly diagnosed MM patients were examined using the Connect MM Registry as well as SEER and NCDB databases. Baseline characteristics predictive of longer survival in Connect MM were also identified. Results: As of February 2017, 3011 patients were enrolled in the Connect MM Registry; 2912 were treated. Median age at time of MM diagnosis and age range were numerically similar from 2010 to 2015 across all 3 registries; SEER had a higher representation of nonwhite racial groups than that in the other 2 registries. OS rates suggest proportionate improvement with year of diagnosis among the 3 registries. A Cox proportional hazards model suggests that younger age (<65 years) is associated with longer survival (vs ≥75; HR, 0.39; 95% confidence interval, 0.34-0.46) in the Connect MM Registry. However, sex (HR, 0.91; P =.15) and race (black vs white; HR, 0.88; P =.21) were not associated with longer OS. Conclusions: Data from the Connect MM Registry appear to be largely representative of national trends, comprehensive, and reliable representations of the national MM population. Baseline characteristics were comparable, and survival similarly improved over time among the 3 registries. ClinicalTrials.gov, identifier: NCT01081028.

Original languageEnglish (US)
Pages (from-to)35-42
Number of pages8
JournalCancer Medicine
Volume9
Issue number1
DOIs
StatePublished - Jan 1 2020

Fingerprint

Multiple Myeloma
Registries
Survival
Databases
Epidemiology
Proportional Hazards Models
Neoplasms
Survival Rate
Confidence Intervals

Keywords

  • multiple myeloma
  • registries
  • survival

ASJC Scopus subject areas

  • Oncology
  • Radiology Nuclear Medicine and imaging
  • Cancer Research

Cite this

Connect MM Registry as a national reference for United States multiple myeloma patients. / on behalf of Connect MM Registry Investigators.

In: Cancer Medicine, Vol. 9, No. 1, 01.01.2020, p. 35-42.

Research output: Contribution to journalArticle

on behalf of Connect MM Registry Investigators. / Connect MM Registry as a national reference for United States multiple myeloma patients. In: Cancer Medicine. 2020 ; Vol. 9, No. 1. pp. 35-42.
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abstract = "Background: The Surveillance, Epidemiology, and End Results (SEER) database and National Cancer Database (NCDB) show improved overall survival (OS) in patients with multiple myeloma (MM) over the last 15 years. This analysis evaluated the validity of the largely community-based Connect MM Registry as a national reference for MM. Methods: Baseline disease characteristics and survival in US newly diagnosed MM patients were examined using the Connect MM Registry as well as SEER and NCDB databases. Baseline characteristics predictive of longer survival in Connect MM were also identified. Results: As of February 2017, 3011 patients were enrolled in the Connect MM Registry; 2912 were treated. Median age at time of MM diagnosis and age range were numerically similar from 2010 to 2015 across all 3 registries; SEER had a higher representation of nonwhite racial groups than that in the other 2 registries. OS rates suggest proportionate improvement with year of diagnosis among the 3 registries. A Cox proportional hazards model suggests that younger age (<65 years) is associated with longer survival (vs ≥75; HR, 0.39; 95{\%} confidence interval, 0.34-0.46) in the Connect MM Registry. However, sex (HR, 0.91; P =.15) and race (black vs white; HR, 0.88; P =.21) were not associated with longer OS. Conclusions: Data from the Connect MM Registry appear to be largely representative of national trends, comprehensive, and reliable representations of the national MM population. Baseline characteristics were comparable, and survival similarly improved over time among the 3 registries. ClinicalTrials.gov, identifier: NCT01081028.",
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author = "{on behalf of Connect MM Registry Investigators} and Sikander Ailawadhi and Sundar Jagannath and Mohit Narang and Rifkin, {Robert M.} and Terebelo, {Howard R.} and Kathleen Toomey and Durie, {Brian G.M.} and Hardin, {James W.} and Gasparetto, {Cristina J.} and Lynne Wagner and Omel, {James L.} and Vivek Kumar and Lihua Yue and Amani Kitali and Amit Agarwal and Rafat Abonour",
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T1 - Connect MM Registry as a national reference for United States multiple myeloma patients

AU - on behalf of Connect MM Registry Investigators

AU - Ailawadhi, Sikander

AU - Jagannath, Sundar

AU - Narang, Mohit

AU - Rifkin, Robert M.

AU - Terebelo, Howard R.

AU - Toomey, Kathleen

AU - Durie, Brian G.M.

AU - Hardin, James W.

AU - Gasparetto, Cristina J.

AU - Wagner, Lynne

AU - Omel, James L.

AU - Kumar, Vivek

AU - Yue, Lihua

AU - Kitali, Amani

AU - Agarwal, Amit

AU - Abonour, Rafat

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N2 - Background: The Surveillance, Epidemiology, and End Results (SEER) database and National Cancer Database (NCDB) show improved overall survival (OS) in patients with multiple myeloma (MM) over the last 15 years. This analysis evaluated the validity of the largely community-based Connect MM Registry as a national reference for MM. Methods: Baseline disease characteristics and survival in US newly diagnosed MM patients were examined using the Connect MM Registry as well as SEER and NCDB databases. Baseline characteristics predictive of longer survival in Connect MM were also identified. Results: As of February 2017, 3011 patients were enrolled in the Connect MM Registry; 2912 were treated. Median age at time of MM diagnosis and age range were numerically similar from 2010 to 2015 across all 3 registries; SEER had a higher representation of nonwhite racial groups than that in the other 2 registries. OS rates suggest proportionate improvement with year of diagnosis among the 3 registries. A Cox proportional hazards model suggests that younger age (<65 years) is associated with longer survival (vs ≥75; HR, 0.39; 95% confidence interval, 0.34-0.46) in the Connect MM Registry. However, sex (HR, 0.91; P =.15) and race (black vs white; HR, 0.88; P =.21) were not associated with longer OS. Conclusions: Data from the Connect MM Registry appear to be largely representative of national trends, comprehensive, and reliable representations of the national MM population. Baseline characteristics were comparable, and survival similarly improved over time among the 3 registries. ClinicalTrials.gov, identifier: NCT01081028.

AB - Background: The Surveillance, Epidemiology, and End Results (SEER) database and National Cancer Database (NCDB) show improved overall survival (OS) in patients with multiple myeloma (MM) over the last 15 years. This analysis evaluated the validity of the largely community-based Connect MM Registry as a national reference for MM. Methods: Baseline disease characteristics and survival in US newly diagnosed MM patients were examined using the Connect MM Registry as well as SEER and NCDB databases. Baseline characteristics predictive of longer survival in Connect MM were also identified. Results: As of February 2017, 3011 patients were enrolled in the Connect MM Registry; 2912 were treated. Median age at time of MM diagnosis and age range were numerically similar from 2010 to 2015 across all 3 registries; SEER had a higher representation of nonwhite racial groups than that in the other 2 registries. OS rates suggest proportionate improvement with year of diagnosis among the 3 registries. A Cox proportional hazards model suggests that younger age (<65 years) is associated with longer survival (vs ≥75; HR, 0.39; 95% confidence interval, 0.34-0.46) in the Connect MM Registry. However, sex (HR, 0.91; P =.15) and race (black vs white; HR, 0.88; P =.21) were not associated with longer OS. Conclusions: Data from the Connect MM Registry appear to be largely representative of national trends, comprehensive, and reliable representations of the national MM population. Baseline characteristics were comparable, and survival similarly improved over time among the 3 registries. ClinicalTrials.gov, identifier: NCT01081028.

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