Connexins and Pannexins in Bone and Skeletal Muscle

Lilian Plotkin, Hannah M. Davis, Bruno A. Cisterna, Juan C. Sáez

Research output: Contribution to journalReview article

6 Citations (Scopus)

Abstract

Purpose of review: To discuss current knowledge on the role of connexins and pannexins in the musculoskeletal system. Recent findings: Connexins and pannexins are crucial for the development and maintenance of both bone and skeletal muscle. In bone, the presence of connexin and more recently of pannexin channels in osteoblasts, osteoclasts, and osteocytes has been described and shown to be essential for normal skeletal development and bone adaptation. In skeletal muscles, connexins and pannexins play important roles during development and regeneration through coordinated regulation of metabolic functions via cell-to-cell communication. Further, under pathological conditions, altered expression of these proteins can promote muscle atrophy and degeneration by stimulating inflammasome activity. Summary: In this review, we highlight the important roles of connexins and pannexins in the development, maintenance, and regeneration of musculoskeletal tissues, with emphasis on the mechanisms by which these molecules mediate chemical (e.g., ATP and prostaglandin E2) and physical (e.g., mechanical stimulation) stimuli that target the musculoskeletal system and their involvement in the pathophysiological changes in both genetic and acquired diseases.

Original languageEnglish (US)
Pages (from-to)326-334
Number of pages9
JournalCurrent Osteoporosis Reports
Volume15
Issue number4
DOIs
StatePublished - Aug 1 2017

Fingerprint

Connexins
Skeletal Muscle
Bone and Bones
Musculoskeletal System
Regeneration
Maintenance
Inflammasomes
Osteocytes
Inborn Genetic Diseases
Muscular Atrophy
Bone Development
Osteoclasts
Osteoblasts
Dinoprostone
Cell Communication
Adenosine Triphosphate
Proteins

Keywords

  • Connexon
  • Gap junctions
  • Hemichannels
  • Inflammation

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism

Cite this

Connexins and Pannexins in Bone and Skeletal Muscle. / Plotkin, Lilian; Davis, Hannah M.; Cisterna, Bruno A.; Sáez, Juan C.

In: Current Osteoporosis Reports, Vol. 15, No. 4, 01.08.2017, p. 326-334.

Research output: Contribution to journalReview article

Plotkin, Lilian ; Davis, Hannah M. ; Cisterna, Bruno A. ; Sáez, Juan C. / Connexins and Pannexins in Bone and Skeletal Muscle. In: Current Osteoporosis Reports. 2017 ; Vol. 15, No. 4. pp. 326-334.
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