Connexins and pannexins in the skeleton

Gap junctions, hemichannels and more

Lilian Plotkin, Joseph P. Stains

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Regulation of bone homeostasis depends on the concerted actions of bone-forming osteoblasts and bone-resorbing osteoclasts, controlled by osteocytes, cells derived from osteoblasts surrounded by bone matrix. The control of differentiation, viability and function of bone cells relies on the presence of connexins. Connexin43 regulates the expression of genes required for osteoblast and osteoclast differentiation directly or by changing the levels of osteocytic genes, and connexin45 may oppose connexin43 actions in osteoblastic cells. Connexin37 is required for osteoclast differentiation and its deletion results in increased bone mass. Less is known on the role of connexins in cartilage, ligaments and tendons. Connexin43, connexin45, connexin32, connexin46 and connexin29 are expressed in chondrocytes, while connexin43 and connexin32 are expressed in ligaments and tendons. Similarly, although the expression of pannexin1, pannexin2 and pannexin3 has been demonstrated in bone and cartilage cells, their function in these tissues is not fully understood.

Original languageEnglish (US)
Pages (from-to)2853-2867
Number of pages15
JournalCellular and Molecular Life Sciences
Volume72
Issue number15
DOIs
StatePublished - Jun 20 2015

Fingerprint

Connexins
Gap Junctions
Skeleton
Connexin 43
Bone and Bones
Osteoclasts
Osteoblasts
Ligaments
Tendons
Cartilage
Osteocytes
Bone Matrix
Chondrocytes
Homeostasis
Gene Expression
Genes

Keywords

  • Bone
  • Cartilage
  • Connexin
  • Ligament
  • Pannexin
  • Tendon

ASJC Scopus subject areas

  • Cell Biology
  • Molecular Biology
  • Molecular Medicine
  • Pharmacology
  • Cellular and Molecular Neuroscience

Cite this

Connexins and pannexins in the skeleton : Gap junctions, hemichannels and more. / Plotkin, Lilian; Stains, Joseph P.

In: Cellular and Molecular Life Sciences, Vol. 72, No. 15, 20.06.2015, p. 2853-2867.

Research output: Contribution to journalArticle

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