Consensus of German transplant centers on hematopoietic stem cell transplantation in Fanconi anemia

M. M. Chao, W. Ebell, P. Bader, R. Beier, B. Burkhardt, T. Feuchtinger, R. Handgretinger, H. Hanenberg, U. Koehl, C. Kratz, B. Kremens, P. Lang, R. Meisel, I. Mueller, C. Roessig, M. Sauer, P. G. Schlegel, A. Schulz, B. Strahm, F. TholK. W. Sykora

Research output: Contribution to journalArticle

7 Scopus citations

Abstract

Allogeneic hematopoietic stem cell transplantation (HSCT) is currently the only curative therapy for the severe hematopoietic complications associated with Fanconi anemia (FA). In Germany, it is estimated that 10-15 transplants are performed annually for FA. However, because FA is a DNA repair disorder, standard conditioning regimens confer a high risk of excessive regimen-related toxicities and mortality, and reduced intensity regimens are linked with graft failure in some FA patients. Moreover, development of graft-versus-host disease is a major contributing factor for secondary solid tumors. The relative rarity of the disorder limits HSCT experience at any single center. Consensus meetings were convened to develop a national approach for HSCT in FA. This manuscript outlines current experience and knowledge about HSCT in FA and, based on this analysis, general recommendations reached at these meetings.

Original languageEnglish (US)
Pages (from-to)157-165
Number of pages9
JournalKlinische Padiatrie
Volume227
Issue number3
DOIs
StatePublished - May 22 2015

Keywords

  • consensus
  • fanconi anemia
  • recommendations
  • stem cell transplantation

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

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    Chao, M. M., Ebell, W., Bader, P., Beier, R., Burkhardt, B., Feuchtinger, T., Handgretinger, R., Hanenberg, H., Koehl, U., Kratz, C., Kremens, B., Lang, P., Meisel, R., Mueller, I., Roessig, C., Sauer, M., Schlegel, P. G., Schulz, A., Strahm, B., ... Sykora, K. W. (2015). Consensus of German transplant centers on hematopoietic stem cell transplantation in Fanconi anemia. Klinische Padiatrie, 227(3), 157-165. https://doi.org/10.1055/s-0035-1548841