Consensus proposals for the prevention of acute and delayed vomiting and nausea following high-emetic-risk chemotherapy

Mark G. Kris, Paul J. Hesketh, Jorn Herrstedt, Cynthia Rittenberg, Lawrence H. Einhorn, Steven Grunberg, Jim Koeller, Ian Olver, Sussanne Borjeson, Enzo Ballatori

Research output: Contribution to journalReview article

99 Scopus citations

Abstract

This paper uses an evidence-based approach whenever possible to formulate recommendations, emphasizing the results of controlled trials concerning the best use of antiemetic agents. We address issues of dose, schedule, and route of administration of five selective 5-HT3 antagonists. We conclude that for each of these five drugs, there is a plateau in therapeutic efficacy above which further dose escalation does not improve outcome. Furthermore, for all classes of antiemetic agents, a single dose is as effective as multiple doses or a continuous infusion. The oral route is as efficacious as the intravenous route of administration, even with chemotherapy of high emetic risk. Selective antagonists of the type 3 serotonin receptor (5-HT3) in combination with dexamethasone and aprepitant are the standard of care for the prevention of emesis following chemotherapy of high emetic risk.

Original languageEnglish (US)
Pages (from-to)85-96
Number of pages12
JournalSupportive Care in Cancer
Volume13
Issue number2
DOIs
StatePublished - Feb 2005

    Fingerprint

Keywords

  • Aprepitant
  • Chemotherapy
  • Cisplatin
  • Dexamethasone
  • Serotonin antagonists

ASJC Scopus subject areas

  • Oncology

Cite this

Kris, M. G., Hesketh, P. J., Herrstedt, J., Rittenberg, C., Einhorn, L. H., Grunberg, S., Koeller, J., Olver, I., Borjeson, S., & Ballatori, E. (2005). Consensus proposals for the prevention of acute and delayed vomiting and nausea following high-emetic-risk chemotherapy. Supportive Care in Cancer, 13(2), 85-96. https://doi.org/10.1007/s00520-004-0699-x