Consensus statement

Guide to bone health and disease in cystic fibrosis

Robert M. Aris, Peter A. Merkel, Laura K. Bachrach, Drucy S. Borowitz, Micheal P. Boyle, Sarah L. Elkin, Theresa Guise, Dana S. Hardin, Charles S. Haworth, Michael F. Holick, Patricia M. Joseph, Kimberly O'Brien, Elizabeth Tullis, Nelson B. Watts, Terry B. White

Research output: Contribution to journalArticle

273 Citations (Scopus)

Abstract

Cystic fibrosis (CF) is the most common genetic disease within the Caucasian population and leads to premature respiratory failure. Approximately 60,000 individuals are currently living with CF in North America and Europe, 40% of whom are adults. The life span of these patients has increased from approximately 2 to 32 yr of age over the last three decades. Bone disease has emerged as a common complication in long-term survivors of CF. Some studies have observed that 50-75% of adults have low bone density and increased rates of fractures. Prevention and treatment of CF-related bone disease must address the myriad risk factors (decreased absorption of fat-soluble vitamins due to pancreatic insufficiency, altered sex hormone production, chronic lung infection with increased levels of bone-active cytokines, physical inactivity, and glucocorticoid therapy) for poor bone health. This review is a condensed and updated summary of the Guide to Bone Health and Disease in Cystic Fibrosis: A Consensus Conference, a statement that evolved from a meeting convened by the Cystic Fibrosis Foundation in May 2002 to address the pathogenesis, diagnosis, and treatment of bone disease in CF. The goal of this conference was to develop practice guidelines for optimizing bone health in patients with CF.

Original languageEnglish (US)
Pages (from-to)1888-1896
Number of pages9
JournalJournal of Clinical Endocrinology and Metabolism
Volume90
Issue number3
DOIs
StatePublished - Mar 2005
Externally publishedYes

Fingerprint

Bone Diseases
Cystic Fibrosis
Bone
Health
Bone and Bones
Exocrine Pancreatic Insufficiency
Inborn Genetic Diseases
Gonadal Steroid Hormones
North America
Practice Guidelines
Vitamins
Respiratory Insufficiency
Bone Density
Glucocorticoids
Survivors
Therapeutics
Fats
Cytokines
Lung
Infection

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology, Diabetes and Metabolism

Cite this

Aris, R. M., Merkel, P. A., Bachrach, L. K., Borowitz, D. S., Boyle, M. P., Elkin, S. L., ... White, T. B. (2005). Consensus statement: Guide to bone health and disease in cystic fibrosis. Journal of Clinical Endocrinology and Metabolism, 90(3), 1888-1896. https://doi.org/10.1210/jc.2004-1629

Consensus statement : Guide to bone health and disease in cystic fibrosis. / Aris, Robert M.; Merkel, Peter A.; Bachrach, Laura K.; Borowitz, Drucy S.; Boyle, Micheal P.; Elkin, Sarah L.; Guise, Theresa; Hardin, Dana S.; Haworth, Charles S.; Holick, Michael F.; Joseph, Patricia M.; O'Brien, Kimberly; Tullis, Elizabeth; Watts, Nelson B.; White, Terry B.

In: Journal of Clinical Endocrinology and Metabolism, Vol. 90, No. 3, 03.2005, p. 1888-1896.

Research output: Contribution to journalArticle

Aris, RM, Merkel, PA, Bachrach, LK, Borowitz, DS, Boyle, MP, Elkin, SL, Guise, T, Hardin, DS, Haworth, CS, Holick, MF, Joseph, PM, O'Brien, K, Tullis, E, Watts, NB & White, TB 2005, 'Consensus statement: Guide to bone health and disease in cystic fibrosis', Journal of Clinical Endocrinology and Metabolism, vol. 90, no. 3, pp. 1888-1896. https://doi.org/10.1210/jc.2004-1629
Aris, Robert M. ; Merkel, Peter A. ; Bachrach, Laura K. ; Borowitz, Drucy S. ; Boyle, Micheal P. ; Elkin, Sarah L. ; Guise, Theresa ; Hardin, Dana S. ; Haworth, Charles S. ; Holick, Michael F. ; Joseph, Patricia M. ; O'Brien, Kimberly ; Tullis, Elizabeth ; Watts, Nelson B. ; White, Terry B. / Consensus statement : Guide to bone health and disease in cystic fibrosis. In: Journal of Clinical Endocrinology and Metabolism. 2005 ; Vol. 90, No. 3. pp. 1888-1896.
@article{1316e5f33b704f2e9aaa320bb4535f2d,
title = "Consensus statement: Guide to bone health and disease in cystic fibrosis",
abstract = "Cystic fibrosis (CF) is the most common genetic disease within the Caucasian population and leads to premature respiratory failure. Approximately 60,000 individuals are currently living with CF in North America and Europe, 40{\%} of whom are adults. The life span of these patients has increased from approximately 2 to 32 yr of age over the last three decades. Bone disease has emerged as a common complication in long-term survivors of CF. Some studies have observed that 50-75{\%} of adults have low bone density and increased rates of fractures. Prevention and treatment of CF-related bone disease must address the myriad risk factors (decreased absorption of fat-soluble vitamins due to pancreatic insufficiency, altered sex hormone production, chronic lung infection with increased levels of bone-active cytokines, physical inactivity, and glucocorticoid therapy) for poor bone health. This review is a condensed and updated summary of the Guide to Bone Health and Disease in Cystic Fibrosis: A Consensus Conference, a statement that evolved from a meeting convened by the Cystic Fibrosis Foundation in May 2002 to address the pathogenesis, diagnosis, and treatment of bone disease in CF. The goal of this conference was to develop practice guidelines for optimizing bone health in patients with CF.",
author = "Aris, {Robert M.} and Merkel, {Peter A.} and Bachrach, {Laura K.} and Borowitz, {Drucy S.} and Boyle, {Micheal P.} and Elkin, {Sarah L.} and Theresa Guise and Hardin, {Dana S.} and Haworth, {Charles S.} and Holick, {Michael F.} and Joseph, {Patricia M.} and Kimberly O'Brien and Elizabeth Tullis and Watts, {Nelson B.} and White, {Terry B.}",
year = "2005",
month = "3",
doi = "10.1210/jc.2004-1629",
language = "English (US)",
volume = "90",
pages = "1888--1896",
journal = "Journal of Clinical Endocrinology and Metabolism",
issn = "0021-972X",
publisher = "The Endocrine Society",
number = "3",

}

TY - JOUR

T1 - Consensus statement

T2 - Guide to bone health and disease in cystic fibrosis

AU - Aris, Robert M.

AU - Merkel, Peter A.

AU - Bachrach, Laura K.

AU - Borowitz, Drucy S.

AU - Boyle, Micheal P.

AU - Elkin, Sarah L.

AU - Guise, Theresa

AU - Hardin, Dana S.

AU - Haworth, Charles S.

AU - Holick, Michael F.

AU - Joseph, Patricia M.

AU - O'Brien, Kimberly

AU - Tullis, Elizabeth

AU - Watts, Nelson B.

AU - White, Terry B.

PY - 2005/3

Y1 - 2005/3

N2 - Cystic fibrosis (CF) is the most common genetic disease within the Caucasian population and leads to premature respiratory failure. Approximately 60,000 individuals are currently living with CF in North America and Europe, 40% of whom are adults. The life span of these patients has increased from approximately 2 to 32 yr of age over the last three decades. Bone disease has emerged as a common complication in long-term survivors of CF. Some studies have observed that 50-75% of adults have low bone density and increased rates of fractures. Prevention and treatment of CF-related bone disease must address the myriad risk factors (decreased absorption of fat-soluble vitamins due to pancreatic insufficiency, altered sex hormone production, chronic lung infection with increased levels of bone-active cytokines, physical inactivity, and glucocorticoid therapy) for poor bone health. This review is a condensed and updated summary of the Guide to Bone Health and Disease in Cystic Fibrosis: A Consensus Conference, a statement that evolved from a meeting convened by the Cystic Fibrosis Foundation in May 2002 to address the pathogenesis, diagnosis, and treatment of bone disease in CF. The goal of this conference was to develop practice guidelines for optimizing bone health in patients with CF.

AB - Cystic fibrosis (CF) is the most common genetic disease within the Caucasian population and leads to premature respiratory failure. Approximately 60,000 individuals are currently living with CF in North America and Europe, 40% of whom are adults. The life span of these patients has increased from approximately 2 to 32 yr of age over the last three decades. Bone disease has emerged as a common complication in long-term survivors of CF. Some studies have observed that 50-75% of adults have low bone density and increased rates of fractures. Prevention and treatment of CF-related bone disease must address the myriad risk factors (decreased absorption of fat-soluble vitamins due to pancreatic insufficiency, altered sex hormone production, chronic lung infection with increased levels of bone-active cytokines, physical inactivity, and glucocorticoid therapy) for poor bone health. This review is a condensed and updated summary of the Guide to Bone Health and Disease in Cystic Fibrosis: A Consensus Conference, a statement that evolved from a meeting convened by the Cystic Fibrosis Foundation in May 2002 to address the pathogenesis, diagnosis, and treatment of bone disease in CF. The goal of this conference was to develop practice guidelines for optimizing bone health in patients with CF.

UR - http://www.scopus.com/inward/record.url?scp=20144389008&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=20144389008&partnerID=8YFLogxK

U2 - 10.1210/jc.2004-1629

DO - 10.1210/jc.2004-1629

M3 - Article

VL - 90

SP - 1888

EP - 1896

JO - Journal of Clinical Endocrinology and Metabolism

JF - Journal of Clinical Endocrinology and Metabolism

SN - 0021-972X

IS - 3

ER -