Conserved lipoprotein H.8 of pathogenic Neisseria consists entirely of pentapeptide repeats

J. P. Woods, S. M. Spinola, S. M. Strobel, J. G. Cannon

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27 Scopus citations


The pathogenic Neisseria, N. gonorrhoeae and N. meningitidis, possess an outer membrane protein (OMP), designated H.8, with a conserved monoclonal antibody (MAb)‐binding epitope. We determined the DNA sequence of a gonococcal H.8 gene, and confirmed the relationship between the cloned gene and the H.8 OMP by constructing a gonococcal mutant lacking H.8. The predicted H.8 OMP is a lipoprotein 71 amino acids in length, composed of 13 repeats of a consensus sequence AAEAP with perfect 5‐residue periodicity. The AAEAP units form a repeating epitope that comprises the entire predicted sequence of the protein.

Original languageEnglish (US)
Pages (from-to)43-48
Number of pages6
JournalMolecular Microbiology
Issue number1
StatePublished - Jan 1989


ASJC Scopus subject areas

  • Microbiology
  • Molecular Biology

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