Constitutively active STAT6 predisposes toward a lymphoproliferative disorder

Mark Kaplan, Sarita Sehra, Hua Chen Chang, John T. O'Malley, Anubhav N. Mathur, Heather A. Bruns

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Signal transducer and activator of transcription 6 (STAT6) is critical for IL-4 and IL-13 responses, and necessary for the normal development of Th2 cells. We previously generated mice that express a constitutively active STAT6 (STAT6VT) under control of the CD2 locus control region, which directs expression to the T-cell compartment. We now describe that a small proportion of these mice (∼5%) develop a spontaneous lymphoproliferative disease (LPD) that results in dramatic splenomegaly. The cell populations observed in the LPD spleens can be divided into 2 categories, those that are composed of mixed lineage cells and those that are predominantly T cells with a phenotype similar to that in autoimmune lymphoproliferative syndrome (ALPS) patients. These data suggest that while active STAT6 is not a transforming factor, expression in T cells predisposes toward the development of lymphoproliferative disorders.

Original languageEnglish
Pages (from-to)4367-4369
Number of pages3
JournalBlood
Volume110
Issue number13
DOIs
StatePublished - Dec 15 2007

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STAT6 Transcription Factor
T-cells
Lymphoproliferative Disorders
T-Lymphocytes
Autoimmune Lymphoproliferative Syndrome
Locus Control Region
Th2 Cells
Interleukin-13
Splenomegaly
Interleukin-4
Spleen
Cells
Phenotype
Population

ASJC Scopus subject areas

  • Hematology

Cite this

Kaplan, M., Sehra, S., Chang, H. C., O'Malley, J. T., Mathur, A. N., & Bruns, H. A. (2007). Constitutively active STAT6 predisposes toward a lymphoproliferative disorder. Blood, 110(13), 4367-4369. https://doi.org/10.1182/blood-2007-06-098244

Constitutively active STAT6 predisposes toward a lymphoproliferative disorder. / Kaplan, Mark; Sehra, Sarita; Chang, Hua Chen; O'Malley, John T.; Mathur, Anubhav N.; Bruns, Heather A.

In: Blood, Vol. 110, No. 13, 15.12.2007, p. 4367-4369.

Research output: Contribution to journalArticle

Kaplan, M, Sehra, S, Chang, HC, O'Malley, JT, Mathur, AN & Bruns, HA 2007, 'Constitutively active STAT6 predisposes toward a lymphoproliferative disorder', Blood, vol. 110, no. 13, pp. 4367-4369. https://doi.org/10.1182/blood-2007-06-098244
Kaplan M, Sehra S, Chang HC, O'Malley JT, Mathur AN, Bruns HA. Constitutively active STAT6 predisposes toward a lymphoproliferative disorder. Blood. 2007 Dec 15;110(13):4367-4369. https://doi.org/10.1182/blood-2007-06-098244
Kaplan, Mark ; Sehra, Sarita ; Chang, Hua Chen ; O'Malley, John T. ; Mathur, Anubhav N. ; Bruns, Heather A. / Constitutively active STAT6 predisposes toward a lymphoproliferative disorder. In: Blood. 2007 ; Vol. 110, No. 13. pp. 4367-4369.
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