Construction of bivalent vaccine candidate expressing CS3 fimbriae and cholera toxin B subunit

Zizheng Dong, Shuqin Li, Zhaoshan Zhang

Research output: Contribution to journalArticle

Abstract

Enterotoxigenic Escherichia coli (ETEC) is one of the most important pathogens of diarrhea in children under age 5 years and in travelers. A multicomponent vaccine made up of anti-colonization factor immunity plus toxoids may provide the best immune stimulation. A recombinant strain which could express bivalent antigens of CS3 fimbriae and cholera toxin B subunit (CT-B) was constructed using plasmid vector bluescript. Inoculating mice orally and immunizing rabbits intramuscularly demonstrated that the recombinant strain could induce immune response against the two antigens.

Original languageEnglish (US)
Pages (from-to)348-351
Number of pages4
JournalChinese Journal of Microbiology and Immunology
Volume17
Issue number5
StatePublished - Sep 1 1997

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Keywords

  • CS3 fimbriae
  • CT-B
  • Escherichia coli
  • Genetic vaccine

ASJC Scopus subject areas

  • Microbiology
  • Immunology
  • Virology

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