Contamination of the pleural surfaces in childhood sarcoma

Use of colloidal P-32 to reduce radiation dose to the whole lung

Joseph F. Montebello, Lech Papiez, Aslam R. Siddiqui, Philip P. Brietfeld, Jay Grosfeld, L. R. Scherer

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Children with pulmonary sarcomas who have diffuse contamination of the pleural cavity present a difficult management problem for the radiation oncologist. Doses required to control even microscopic disease exceed lung tolerance. We report on the use of intracavity colloid P-32 in an attempt to treat the pleural surface and spare normal lung parenchyma and tissues of the chest wall. Three children - 18 months, 12 years, and 3 years of age - had spillage of pulmonary sarcomas into the chest cavity. All children were treated with systemic chemotherapy. Initially, 0.5 mCi of technetium sulfur colloid (99mTc-sulfur colloid) was instilled into the pleural space to ascertain even distribution of isotope. This was then followed by installation of 5.0 mCi of colloidal P-32. Uniform distribution was then confirmed by bremsstrahlung scanning. All three patients are in complete remission 3.5 years, 3 years, and 1 year after treatment, respectively. The major toxicity was asymptomatic pleural thickening, which could be confused with disease. This was confirmed histologically to be fibrous in the first patient. The process diminished or stabilized with time in all 3 patients over the period of observation. In this small series, intrapleural colloidal P-32 appeared to be safe and well tolerated and would be expected to be less toxic than wide-field external beam in the treatment of spilled pulmonary sarcomas.

Original languageEnglish
Pages (from-to)587-591
Number of pages5
JournalAmerican Journal of Clinical Oncology: Cancer Clinical Trials
Volume20
Issue number6
DOIs
StatePublished - Dec 1997

Fingerprint

Sarcoma
Radiation
Lung
Colloids
Technetium Tc 99m Sulfur Colloid
Pleural Cavity
Poisons
Thoracic Wall
Sulfur
Isotopes
Lung Diseases
Thorax
Observation
Drug Therapy
Therapeutics

Keywords

  • Colloidal chromic P-32
  • Pulmonary sarcomas

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Contamination of the pleural surfaces in childhood sarcoma : Use of colloidal P-32 to reduce radiation dose to the whole lung. / Montebello, Joseph F.; Papiez, Lech; Siddiqui, Aslam R.; Brietfeld, Philip P.; Grosfeld, Jay; Scherer, L. R.

In: American Journal of Clinical Oncology: Cancer Clinical Trials, Vol. 20, No. 6, 12.1997, p. 587-591.

Research output: Contribution to journalArticle

Montebello, Joseph F. ; Papiez, Lech ; Siddiqui, Aslam R. ; Brietfeld, Philip P. ; Grosfeld, Jay ; Scherer, L. R. / Contamination of the pleural surfaces in childhood sarcoma : Use of colloidal P-32 to reduce radiation dose to the whole lung. In: American Journal of Clinical Oncology: Cancer Clinical Trials. 1997 ; Vol. 20, No. 6. pp. 587-591.
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