Continuous arteriovenous rewarming: Experimental results and thermodynamic model simulation of treatment for hypothermia

Larry M. Gentilello, Vicente Cortes, Samir Moujaes, Manuel Viamonte, Theodore L. Malinin, Chih Hsiang Ho, G. A. Gomez

Research output: Contribution to journalArticle

55 Citations (Scopus)

Abstract

We evaluated a technique for treating hypothermia that uses extracorporeal circulation but does not require heparin or pump assistance. Hypothermia to 29.5°C was induced in eight anesthetized dogs, and thermistors placed in the pulmonary artery, liver, bladder, esophagus, rectum, muscle, and skin. Four experimental animals were rewarmed by creating a fistula which connected arterial and venous femoral lines to an interposed counter-current heat exchanger. External rewarming was used in four controls. Bleeding time (BT), coagulation profile (PT, PTT, TT), and cardiac output (CO) were measured during rewarming. Core temperature (T) rose significantly faster with CAVR (0.00001). Average time to rewarming was 45 min, vs. 4 hrs in controls. Haptoglobin, platelet, fibrinogen, and fibrin split product levels were unaffected. Continuous arteriovenous rewarming (CAVR) improved T, CO, BT, and coagulation profile faster than any method yet reported not requiring heparin or cardiac bypass. The application of CAVR in post-traumatic hypothermia warrants further investigation.

Original languageEnglish (US)
Pages (from-to)1436-1449
Number of pages14
JournalJournal of Trauma - Injury, Infection and Critical Care
Volume30
Issue number12
StatePublished - 1990
Externally publishedYes

Fingerprint

Rewarming
Hypothermia
Thermodynamics
Bleeding Time
Cardiac Output
Heparin
Therapeutics
Fibrin Fibrinogen Degradation Products
Haptoglobins
Extracorporeal Circulation
Thigh
Rectum
Pulmonary Artery
Esophagus
Fistula
Urinary Bladder
Blood Platelets
Hot Temperature
Dogs
Muscles

ASJC Scopus subject areas

  • Critical Care and Intensive Care Medicine
  • Surgery

Cite this

Gentilello, L. M., Cortes, V., Moujaes, S., Viamonte, M., Malinin, T. L., Ho, C. H., & Gomez, G. A. (1990). Continuous arteriovenous rewarming: Experimental results and thermodynamic model simulation of treatment for hypothermia. Journal of Trauma - Injury, Infection and Critical Care, 30(12), 1436-1449.

Continuous arteriovenous rewarming : Experimental results and thermodynamic model simulation of treatment for hypothermia. / Gentilello, Larry M.; Cortes, Vicente; Moujaes, Samir; Viamonte, Manuel; Malinin, Theodore L.; Ho, Chih Hsiang; Gomez, G. A.

In: Journal of Trauma - Injury, Infection and Critical Care, Vol. 30, No. 12, 1990, p. 1436-1449.

Research output: Contribution to journalArticle

Gentilello, LM, Cortes, V, Moujaes, S, Viamonte, M, Malinin, TL, Ho, CH & Gomez, GA 1990, 'Continuous arteriovenous rewarming: Experimental results and thermodynamic model simulation of treatment for hypothermia', Journal of Trauma - Injury, Infection and Critical Care, vol. 30, no. 12, pp. 1436-1449.
Gentilello, Larry M. ; Cortes, Vicente ; Moujaes, Samir ; Viamonte, Manuel ; Malinin, Theodore L. ; Ho, Chih Hsiang ; Gomez, G. A. / Continuous arteriovenous rewarming : Experimental results and thermodynamic model simulation of treatment for hypothermia. In: Journal of Trauma - Injury, Infection and Critical Care. 1990 ; Vol. 30, No. 12. pp. 1436-1449.
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