Contractile force of canine tracheal smooth muscle during continuous stretch

Susan Gunst, J. A. Russell

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Canine tracheal smooth muscle strips were mounted horizontally in a tissue bath between a force transducer and a motor-driven movable steel rod, which was used to change muscle length. Muscle length and force were continuously measured during stretch and simultaneously plotted on an X-Y recorder. Active force during stretch was investigated as follows: an initial length was set with the muscle relaxed, where it was contracted isometrically with acetylcholine. After active force reached a steady state, muscle length was decreased until the total tension was equal to zero. The muscle was then stretched slowly to obtain a continuous length-force curve. Results show that force during stretch increases as the length at which the initial isometric contraction is elicited, is decreased. A possible interpretation is that during tonic muscle contraction, the contractile element is able to shorten very slowly relative to the rate at which the muscle was retracted. Thus, the contractile element length established during isometric contraction would affect the muscle force obtained during subsequent stretch of the muscle.

Original languageEnglish (US)
Pages (from-to)655-663
Number of pages9
JournalJournal of Applied Physiology Respiratory Environmental and Exercise Physiology
Volume52
Issue number3
StatePublished - 1982
Externally publishedYes

Fingerprint

Smooth Muscle
Canidae
Muscles
Isometric Contraction
Steel
Muscle Contraction
Transducers
Baths
Acetylcholine

ASJC Scopus subject areas

  • Endocrinology
  • Physiology

Cite this

@article{ff94afe952754fd79f2a4132315ce265,
title = "Contractile force of canine tracheal smooth muscle during continuous stretch",
abstract = "Canine tracheal smooth muscle strips were mounted horizontally in a tissue bath between a force transducer and a motor-driven movable steel rod, which was used to change muscle length. Muscle length and force were continuously measured during stretch and simultaneously plotted on an X-Y recorder. Active force during stretch was investigated as follows: an initial length was set with the muscle relaxed, where it was contracted isometrically with acetylcholine. After active force reached a steady state, muscle length was decreased until the total tension was equal to zero. The muscle was then stretched slowly to obtain a continuous length-force curve. Results show that force during stretch increases as the length at which the initial isometric contraction is elicited, is decreased. A possible interpretation is that during tonic muscle contraction, the contractile element is able to shorten very slowly relative to the rate at which the muscle was retracted. Thus, the contractile element length established during isometric contraction would affect the muscle force obtained during subsequent stretch of the muscle.",
author = "Susan Gunst and Russell, {J. A.}",
year = "1982",
language = "English (US)",
volume = "52",
pages = "655--663",
journal = "Journal of Applied Physiology",
issn = "8750-7587",
publisher = "American Physiological Society",
number = "3",

}

TY - JOUR

T1 - Contractile force of canine tracheal smooth muscle during continuous stretch

AU - Gunst, Susan

AU - Russell, J. A.

PY - 1982

Y1 - 1982

N2 - Canine tracheal smooth muscle strips were mounted horizontally in a tissue bath between a force transducer and a motor-driven movable steel rod, which was used to change muscle length. Muscle length and force were continuously measured during stretch and simultaneously plotted on an X-Y recorder. Active force during stretch was investigated as follows: an initial length was set with the muscle relaxed, where it was contracted isometrically with acetylcholine. After active force reached a steady state, muscle length was decreased until the total tension was equal to zero. The muscle was then stretched slowly to obtain a continuous length-force curve. Results show that force during stretch increases as the length at which the initial isometric contraction is elicited, is decreased. A possible interpretation is that during tonic muscle contraction, the contractile element is able to shorten very slowly relative to the rate at which the muscle was retracted. Thus, the contractile element length established during isometric contraction would affect the muscle force obtained during subsequent stretch of the muscle.

AB - Canine tracheal smooth muscle strips were mounted horizontally in a tissue bath between a force transducer and a motor-driven movable steel rod, which was used to change muscle length. Muscle length and force were continuously measured during stretch and simultaneously plotted on an X-Y recorder. Active force during stretch was investigated as follows: an initial length was set with the muscle relaxed, where it was contracted isometrically with acetylcholine. After active force reached a steady state, muscle length was decreased until the total tension was equal to zero. The muscle was then stretched slowly to obtain a continuous length-force curve. Results show that force during stretch increases as the length at which the initial isometric contraction is elicited, is decreased. A possible interpretation is that during tonic muscle contraction, the contractile element is able to shorten very slowly relative to the rate at which the muscle was retracted. Thus, the contractile element length established during isometric contraction would affect the muscle force obtained during subsequent stretch of the muscle.

UR - http://www.scopus.com/inward/record.url?scp=0019950539&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0019950539&partnerID=8YFLogxK

M3 - Article

C2 - 7068481

AN - SCOPUS:0019950539

VL - 52

SP - 655

EP - 663

JO - Journal of Applied Physiology

JF - Journal of Applied Physiology

SN - 8750-7587

IS - 3

ER -