Contrast-enhanced mammographic detection of breast microcalcifications using targeted gold nanoparticles

Tyler A. Finamore, Evan P. Gies, Tracy Vargo-Gogola, Ryan K. Roeder

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Statement of Purpose: Hydroxyapatite (HA) microcalcifications (µcals) are the most common abnormality detected in mammographic screening for breast cancer, coincident with 30-50% of all breast cancers and 85-95% of all ductal carcinoma in situ [1,2]. Mammographic screening is the gold standard for early detection of breast cancer, contributing to a 30% decrease in mortality [3], but mammographic sensitivity drops to 36% for women with dense breast tissue versus 98% for women with almost entirely fatty breast tissue [4]. Moreover, dense breast tissue is independently associated with a four-to five-fold increased likelihood of developing breast cancer [5]. Bisphosphonate-functionalized gold nanoparticles (BP-PEG-Au NPs) were recently demonstrated to enable contrast-enhanced detection of μcals that were otherwise undetectable in murine models of both normal and radiographically dense breast tissue [6,7]. However, clinical translation requires further investigation using human-scale anatomic models and clinical imaging instrumentation. Therefore, the objective of this study was to investigate contrast-enhanced mammographic detection of model μcals with BP-PEG-Au NPs in radiographic phantoms with varying breast density.

Original languageEnglish (US)
Title of host publicationSociety for Biomaterials Annual Meeting and Exposition 2019
Subtitle of host publicationThe Pinnacle of Biomaterials Innovation and Excellence - Transactions of the 42nd Annual Meeting
PublisherSociety for Biomaterials
Number of pages1
ISBN (Electronic)9781510883901
StatePublished - Jan 1 2019
Event42nd Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence - Seattle, United States
Duration: Apr 3 2019Apr 6 2019

Publication series

NameTransactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium
Volume40
ISSN (Print)1526-7547

Conference

Conference42nd Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence
CountryUnited States
CitySeattle
Period4/3/194/6/19

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Biotechnology
  • Biomaterials
  • Materials Chemistry

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  • Cite this

    Finamore, T. A., Gies, E. P., Vargo-Gogola, T., & Roeder, R. K. (2019). Contrast-enhanced mammographic detection of breast microcalcifications using targeted gold nanoparticles. In Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence - Transactions of the 42nd Annual Meeting (Transactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium; Vol. 40). Society for Biomaterials.