Contrast issues in brain tumor imaging

N. D. Abdullah, V. P. Mathews

Research output: Contribution to journalReview articlepeer-review

10 Scopus citations


Gd-based MR imaging contrast materials and iodinated CT contrast materials are both strongly indicated in the imaging of brain tumors to improve tumor detection, characterization, and delineation. In patients who are able to undergo MR imaging, CEMRI is generally preferable to contrast- enhanced CT for tumor imaging, especially when detection of small lesions is clinically important or when accurate resolution of tumor boundaries is necessary. Increased Gd dose and use of MT techniques are both effective methods for improving the sensitivity of CEMRI. Optimal Gd dose for CEMRI of tumors depends on tumor type, location, and size; dosages less than standard may be adequate or even superior for some applications. CEMRI is a sensitive but not highly specific modality for detection of tumor residual or recurrence in patients who have undergone treatment for brain tumors. Contrast-based MR imaging techniques, such as dynamic MR imaging and regional cerebral blood flow mapping, are developing and may improve diagnostic efficacy for tumor imaging both before and after treatment.

Original languageEnglish (US)
Pages (from-to)733-749
Number of pages17
JournalNeuroimaging Clinics of North America
Issue number4
StatePublished - Nov 26 1999

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Clinical Neurology

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