Contribution of infralimbic cortex in the cardiovascular response to acute stress

Flávia Camargos de Figueirêdo Müller-Ribeiro, Dmitry Zaretsky, Maria V. Zaretskaia, Robson A S Santos, Joseph A. DiMicco, Marco Antônio Peliky Fontes

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

The infralimbic region of the medial prefrontal cortex (IL) modulates autonomic and neuroendocrine function via projections to subcortical structures involved in the response to stress. We evaluated the contribution of the IL to the cardiovascular response evoked by acute stress. Under anesthesia (80 mg/kg ketamine-11.5 mg/kg xylazine), rats were implanted with telemetry probes or arterial lines for recording heart rate and blood pressure. Guide cannulas were implanted to target the IL for microinjection of muscimol (100 pmol/100 nl), N-methyl-D-aspartate (NMDA) (6 pmol/100 nl), or vehicle (100 nl). Microinjection of muscimol, an agonist of GABAA receptors, into the IL had no effect on stress-evoked cardiovascular and thermogenic changes in any of the paradigms evaluated (cage switch, restraint plus air-jet noise, or air-jet stress). However, microinjection of the excitatory amino acid NMDA into the IL attenuated the pressor and tachycardic response to air-jet stress. Pretreatment with the selective NMDA antagonist DL-2- amino-5-phosphonopentanoic acid (AP-5, 100 pmol/100 nl) blocked the effect of NMDA on the cardiovascular response to air-jet stress. We conclude that 1) the IL region is not tonically involved in cardiovascular or thermogenic control during stress or under baseline conditions, and 2) activation of NMDA receptors in the IL can suppress the cardiovascular response to acute stress exposure.

Original languageEnglish
JournalAmerican Journal of Physiology - Regulatory Integrative and Comparative Physiology
Volume303
Issue number6
DOIs
StatePublished - Sep 15 2012

Fingerprint

N-Methylaspartate
Microinjections
Air
Muscimol
2-Amino-5-phosphonovalerate
Xylazine
Vascular Access Devices
Telemetry
Excitatory Amino Acids
Ketamine
GABA-A Receptors
Prefrontal Cortex
N-Methyl-D-Aspartate Receptors
Interleukin-1
Noise
Anesthesia
Heart Rate
Blood Pressure

Keywords

  • Blood pressure
  • Dorsomedial hypothalamus
  • Heart rate
  • Medial prefrontal cortex

ASJC Scopus subject areas

  • Physiology
  • Physiology (medical)

Cite this

Contribution of infralimbic cortex in the cardiovascular response to acute stress. / Müller-Ribeiro, Flávia Camargos de Figueirêdo; Zaretsky, Dmitry; Zaretskaia, Maria V.; Santos, Robson A S; DiMicco, Joseph A.; Fontes, Marco Antônio Peliky.

In: American Journal of Physiology - Regulatory Integrative and Comparative Physiology, Vol. 303, No. 6, 15.09.2012.

Research output: Contribution to journalArticle

Müller-Ribeiro, Flávia Camargos de Figueirêdo ; Zaretsky, Dmitry ; Zaretskaia, Maria V. ; Santos, Robson A S ; DiMicco, Joseph A. ; Fontes, Marco Antônio Peliky. / Contribution of infralimbic cortex in the cardiovascular response to acute stress. In: American Journal of Physiology - Regulatory Integrative and Comparative Physiology. 2012 ; Vol. 303, No. 6.
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