Contribution of infralimbic cortex in the cardiovascular response to acute stress

Flávia Camargos de Figueirêdo Müller-Ribeiro, Dmitry V. Zaretsky, Maria V. Zaretskaia, Robson A.S. Santos, Joseph A. DiMicco, Marco Antônio Peliky Fontes

Research output: Contribution to journalArticlepeer-review

27 Scopus citations


The infralimbic region of the medial prefrontal cortex (IL) modulates autonomic and neuroendocrine function via projections to subcortical structures involved in the response to stress. We evaluated the contribution of the IL to the cardiovascular response evoked by acute stress. Under anesthesia (80 mg/kg ketamine-11.5 mg/kg xylazine), rats were implanted with telemetry probes or arterial lines for recording heart rate and blood pressure. Guide cannulas were implanted to target the IL for microinjection of muscimol (100 pmol/100 nl), N-methyl-D-aspartate (NMDA) (6 pmol/100 nl), or vehicle (100 nl). Microinjection of muscimol, an agonist of GABAA receptors, into the IL had no effect on stress-evoked cardiovascular and thermogenic changes in any of the paradigms evaluated (cage switch, restraint plus air-jet noise, or air-jet stress). However, microinjection of the excitatory amino acid NMDA into the IL attenuated the pressor and tachycardic response to air-jet stress. Pretreatment with the selective NMDA antagonist DL-2- amino-5-phosphonopentanoic acid (AP-5, 100 pmol/100 nl) blocked the effect of NMDA on the cardiovascular response to air-jet stress. We conclude that 1) the IL region is not tonically involved in cardiovascular or thermogenic control during stress or under baseline conditions, and 2) activation of NMDA receptors in the IL can suppress the cardiovascular response to acute stress exposure.

Original languageEnglish (US)
Pages (from-to)R639-R650
JournalAmerican Journal of Physiology - Regulatory Integrative and Comparative Physiology
Issue number6
StatePublished - Sep 15 2012


  • Blood pressure
  • Dorsomedial hypothalamus
  • Heart rate
  • Medial prefrontal cortex

ASJC Scopus subject areas

  • Physiology
  • Physiology (medical)

Fingerprint Dive into the research topics of 'Contribution of infralimbic cortex in the cardiovascular response to acute stress'. Together they form a unique fingerprint.

Cite this