Contributions of dysglycaemia, obesity, and insulin resistance to impaired endothelium-dependent vasodilation in humans

K. A. Han, Y. Patel, Amale Lteif, R. Chisholm, Kieren Mather

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

Background: Individual effects of hyperglycaemia and obesity to impair vascular health are recognized. However, the relative contributions of dysglycaemia versus other obesity-related traits to vascular dysfunction have not been systematically evaluated. Methods: We undertook a cross-sectional evaluation of factors contributing to vascular function in 271 consecutive subjects, categorized as non-obese normal glucose tolerant (n = 115), non-obese dysglycaemic (n = 32), obese normal glucose tolerant (n = 57), obese dysglycaemic (n = 38), or type 2 diabetic (n = 29). Vascular function was measured invasively as leg blood flow responses to methacholine chloride, an endothelium-dependent vasodilator. Categorical and continuous analyses were carried out to assess the contributions of hyperglycaemia to vascular dysfunction. Results: Even among normoglycaemic subjects, obese subjects had impaired vascular function compared to non-obese subjects (p = 0.004). Vascular function was also impaired in non-obese dysglycaemic subjects (p = 0.04 versus non-obese normoglycaemic subjects), to a level comparable to normoglycaemic obese subjects. Within obese subject groups, gradations of dysglycaemia including the presence of diabetes were not associated with further worsening of these vascular responses beyond the effect of obesity alone (p = not significant comparing all obese groups, p < 0.001 versus lean normoglycaemic subjects). After univariate and multivariable modelling analyses we found that effects of glycaemia were less powerful than effects of insulin resistance and obesity on vascular dysfunction. Conclusions: Dysglycaemia contributes to impaired vascular function in non-obese subjects, but obesity and insulin resistance are more important determinants of vascular function in obese and diabetic subjects.

Original languageEnglish
Pages (from-to)354-361
Number of pages8
JournalDiabetes/Metabolism Research and Reviews
Volume27
Issue number4
DOIs
StatePublished - May 2011

Fingerprint

Vasodilation
Endothelium
Blood Vessels
Insulin Resistance
Obesity
Hyperglycemia
Glucose
Endothelium-Dependent Relaxing Factors
Methacholine Chloride
Leg
Health

Keywords

  • Diabetes
  • Dysglycaemia
  • Endothelium
  • Obesity

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism
  • Internal Medicine

Cite this

Contributions of dysglycaemia, obesity, and insulin resistance to impaired endothelium-dependent vasodilation in humans. / Han, K. A.; Patel, Y.; Lteif, Amale; Chisholm, R.; Mather, Kieren.

In: Diabetes/Metabolism Research and Reviews, Vol. 27, No. 4, 05.2011, p. 354-361.

Research output: Contribution to journalArticle

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