Control of cellular proliferation by the fibroblast and epidermal growth factors.

D. Gospodarowicz, Anthony Mescher, C. R. Birdwell

Research output: Contribution to journalArticle

82 Citations (Scopus)

Abstract

Recent studies on the effect of the fibroblast and epidermal growth factors (FGF and EGF, respectively) on the proliferation of ovarian cells and vascular endothelial cells are reviewed. During the ovarian cycle, luteal cells are derived from granulosa cells by a process of cytomorphosis. These two cell types thus allow a study of the changes that occur in growth control when one cell type is converted into another. Also described is the control of vascular endothelial cell proliferation by FGF (but not by EGF). We discuss the effects of FGF and EGF on cells derived from the embryonic ectoderm, mesoderm, and endoderm and examine the hypothesis that cellular specificity for various growth factors is conferred during embryo development. Finally, since antagonists of growth factors are probably as important as the mitogens in the overall control of cell proliferation, we review certain mechanisms and agents through which the mitogenic effect of FGF can be repressed, i.e., cell-cell interaction at confluence, trophic hormones, and a diffusible factor(s) from cartilage.

Original languageEnglish
Pages (from-to)109-130
Number of pages22
JournalNational Cancer Institute monograph
Issue number48
StatePublished - May 1978
Externally publishedYes

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Fibroblasts
Cell Proliferation
Epidermal Growth Factor
Intercellular Signaling Peptides and Proteins
Endothelial Cells
Luteal Cells
Endoderm
Ectoderm
Granulosa Cells
Mesoderm
Menstrual Cycle
Mitogens
Cell Communication
Cartilage
Embryonic Development
Hormones
EGF Family of Proteins
Growth

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Control of cellular proliferation by the fibroblast and epidermal growth factors. / Gospodarowicz, D.; Mescher, Anthony; Birdwell, C. R.

In: National Cancer Institute monograph, No. 48, 05.1978, p. 109-130.

Research output: Contribution to journalArticle

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