Control of granulopoiesis in man. III. Inhibition of colony formation by dense leukocytes

F. L. Baker, H. E. Broxmeyer, P. R. Galbraith

Research output: Contribution to journalArticlepeer-review

19 Scopus citations

Abstract

Cellular feeder layers, prepared from normal blood leukocytes, usually stimulate human marrow to form colonies. A significant increase in the stimulating activity of unseparated leukocyte feeder layers is brought about following the removal of dense leukocytes in a manner which avoids enrichment of any remaining cell type. Restoration of dense leukocytes to a dense leukocyte depleted leukocyte feeder layer results in the reduction of stimulating activity to that of an unseparated leukocyte feeder; however, addition of dense leukocytes to unseparated leukocyte feeder layers has no effect on the stimulatory activity, over the range of concentrations used in this study.

Original languageEnglish (US)
Pages (from-to)337-342
Number of pages6
JournalJournal of cellular physiology
Volume86
Issue number1 S
DOIs
StatePublished - Oct 1975
Externally publishedYes

ASJC Scopus subject areas

  • Physiology
  • Clinical Biochemistry
  • Cell Biology

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