Control of inflammation, cytokine expression, and germinal center formation by BCL-6

Alexander Dent, Arthur L. Shaffer, Xin Yu, David Allman, Louis M. Staudt

Research output: Contribution to journalArticle

703 Citations (Scopus)

Abstract

The gene encoding the BCL-6 transcriptional repressor is frequently translocated and mutated in diffuse large cell lymphoma. Mice with a disrupted BCL-6 gene developed myocarditis and pulmonary vasculitis, had no germinal centers, and had increased expression of T helper cell type 2 cytokines. The BCL-6 DNA recognition motif resembled sites bound by the STAT (signal transducers and activators of transcription) transcription factors, which mediate cytokine signaling. BCL-6 could repress interleukin-4 (IL-4)- induced transcription when bound to a site recognized by the IL-4-responsive transcription factor Stat6. Thus, dysregulation of STAT-responsive genes may underlie the inflammatory disease in BCL-6 -deficient mice and participate in lymphoid malignancies.

Original languageEnglish (US)
Pages (from-to)589-592
Number of pages4
JournalScience
Volume276
Issue number5312
DOIs
StatePublished - Apr 25 1997
Externally publishedYes

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Germinal Center
Cytokines
Inflammation
Transducers
Interleukin-4
Transcription Factors
Genes
Th2 Cells
Nucleotide Motifs
Lymphoma, Large B-Cell, Diffuse
Myocarditis
Vasculitis
Lung
Neoplasms

ASJC Scopus subject areas

  • General

Cite this

Control of inflammation, cytokine expression, and germinal center formation by BCL-6. / Dent, Alexander; Shaffer, Arthur L.; Yu, Xin; Allman, David; Staudt, Louis M.

In: Science, Vol. 276, No. 5312, 25.04.1997, p. 589-592.

Research output: Contribution to journalArticle

Dent, Alexander ; Shaffer, Arthur L. ; Yu, Xin ; Allman, David ; Staudt, Louis M. / Control of inflammation, cytokine expression, and germinal center formation by BCL-6. In: Science. 1997 ; Vol. 276, No. 5312. pp. 589-592.
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