Control of self-reactivity in the intestine

Terrence A. Barrett, Stephen M. Hedrick, Alexander Dent, Michelle L. Delvy, David M. Kennedy, Louis A. Matis, Jeffrey A. Bluestone

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

In the intestine maintenance of self-tolerance may involve tissue-specific self-Ags, APCs, 'second signals', and extrathymic pathways of T cell maturation. These factors combine to create a unique environment where autoimmune tissue destruction is prevented despite local inflammatory influences. In this review we summarize our findings using a TCR-γδ transgenic model where self-tolerance was maintained by clonal deletion for cells localizing to peripheral lymphold tissue and by clonal anergy for cells localizing to the intraepithelial compartments. Several possible explanations exist for these results but in general, these findings have implications for the maintenance of self-tolerance of normal TCR-αβ and TCR-γδ IELs in epithelial tissues such as the intestine.

Original languageEnglish (US)
Pages (from-to)341-348
Number of pages8
JournalImmunologic Research
Volume10
Issue number3-4
DOIs
StatePublished - Dec 1991
Externally publishedYes

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Self Tolerance
Intestines
Clonal Anergy
Clonal Deletion
Signal Transduction
Epithelium
T-Lymphocytes

ASJC Scopus subject areas

  • Immunology

Cite this

Barrett, T. A., Hedrick, S. M., Dent, A., Delvy, M. L., Kennedy, D. M., Matis, L. A., & Bluestone, J. A. (1991). Control of self-reactivity in the intestine. Immunologic Research, 10(3-4), 341-348. https://doi.org/10.1007/BF02919719

Control of self-reactivity in the intestine. / Barrett, Terrence A.; Hedrick, Stephen M.; Dent, Alexander; Delvy, Michelle L.; Kennedy, David M.; Matis, Louis A.; Bluestone, Jeffrey A.

In: Immunologic Research, Vol. 10, No. 3-4, 12.1991, p. 341-348.

Research output: Contribution to journalArticle

Barrett, TA, Hedrick, SM, Dent, A, Delvy, ML, Kennedy, DM, Matis, LA & Bluestone, JA 1991, 'Control of self-reactivity in the intestine', Immunologic Research, vol. 10, no. 3-4, pp. 341-348. https://doi.org/10.1007/BF02919719
Barrett TA, Hedrick SM, Dent A, Delvy ML, Kennedy DM, Matis LA et al. Control of self-reactivity in the intestine. Immunologic Research. 1991 Dec;10(3-4):341-348. https://doi.org/10.1007/BF02919719
Barrett, Terrence A. ; Hedrick, Stephen M. ; Dent, Alexander ; Delvy, Michelle L. ; Kennedy, David M. ; Matis, Louis A. ; Bluestone, Jeffrey A. / Control of self-reactivity in the intestine. In: Immunologic Research. 1991 ; Vol. 10, No. 3-4. pp. 341-348.
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