Controlling the editor: The many roles of RNA-binding proteins in regulating A-to-I RNA editing

Michael C. Washburn, Heather Hundley

Research output: Chapter in Book/Report/Conference proceedingChapter

4 Scopus citations

Abstract

RNA editing is a cellular process used to expand and diversify the RNA transcripts produced from a generally immutable genome. In animals, the most prevalent type of RNA editing is adenosine (A) to inosine (I) deamination catalyzed by the ADAR family. Throughout development, A-to-I editing levels increase while ADAR expression is constant, suggesting cellular mechanisms to regulate A-to-I editing exist. Furthermore, in several disease states, ADAR expression levels are similar to the normal state, but A-to-I editing levels are altered. Therefore, understanding how these enzymes are regulated in normal tissues and misregulated in disease states is of profound importance. This chapter will both discuss how to identify A-to-I editing sites across the transcriptome and explore the mechanisms that regulate ADAR editing activity, with particular focus on the diverse types of RNA-binding proteins implicated in regulating A-to-I editing in vivo.

Original languageEnglish (US)
Title of host publicationAdvances in Experimental Medicine and Biology
PublisherSpringer New York LLC
Pages189-213
Number of pages25
Volume907
DOIs
StatePublished - 2016

Publication series

NameAdvances in Experimental Medicine and Biology
Volume907
ISSN (Print)00652598
ISSN (Electronic)22148019

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Keywords

  • ADARs
  • Inosine
  • RNA editing
  • RNA-binding proteins
  • Splicing

ASJC Scopus subject areas

  • Medicine(all)
  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Washburn, M. C., & Hundley, H. (2016). Controlling the editor: The many roles of RNA-binding proteins in regulating A-to-I RNA editing. In Advances in Experimental Medicine and Biology (Vol. 907, pp. 189-213). (Advances in Experimental Medicine and Biology; Vol. 907). Springer New York LLC. https://doi.org/10.1007/978-3-319-29073-7_8