Abstract
The recent development of microarray technologies has made possible the simultaneous measurement of mRNA levels for thousands of genes and a new genomic method termed gene expression profiling. The application of this approach to animal models or post-mortem tissue provides a powerful tool for the discovery of novel genes involved in psychiatric disorders. This approach has strengths that are complementary to those of another genomic method for gene discovery, positional cloning. Microarray technologies and their application to post-mortem tissue and animal models of bipolar disorder are reviewed. A novel approach termed convergent functional genomics, which integrates gene profiling and positional cloning in order to rapidly identify candidate disease genes, is also described.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 263-271 |
| Number of pages | 9 |
| Journal | Annals of Medicine |
| Volume | 33 |
| Issue number | 4 |
| State | Published - 2001 |
| Externally published | Yes |
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Keywords
- Bipolar disorder
- Functional genomics
- Gene expression profiling
- Mania
- Manic-depressive illness
- Microarrays
- Psychosis
ASJC Scopus subject areas
- Medicine(all)
Cite this
Convergent functional genomics : Application to bipolar disorder. / Niculescu, Alexander; Kelsoe, J. R.
In: Annals of Medicine, Vol. 33, No. 4, 2001, p. 263-271.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Convergent functional genomics
T2 - Application to bipolar disorder
AU - Niculescu, Alexander
AU - Kelsoe, J. R.
PY - 2001
Y1 - 2001
N2 - The recent development of microarray technologies has made possible the simultaneous measurement of mRNA levels for thousands of genes and a new genomic method termed gene expression profiling. The application of this approach to animal models or post-mortem tissue provides a powerful tool for the discovery of novel genes involved in psychiatric disorders. This approach has strengths that are complementary to those of another genomic method for gene discovery, positional cloning. Microarray technologies and their application to post-mortem tissue and animal models of bipolar disorder are reviewed. A novel approach termed convergent functional genomics, which integrates gene profiling and positional cloning in order to rapidly identify candidate disease genes, is also described.
AB - The recent development of microarray technologies has made possible the simultaneous measurement of mRNA levels for thousands of genes and a new genomic method termed gene expression profiling. The application of this approach to animal models or post-mortem tissue provides a powerful tool for the discovery of novel genes involved in psychiatric disorders. This approach has strengths that are complementary to those of another genomic method for gene discovery, positional cloning. Microarray technologies and their application to post-mortem tissue and animal models of bipolar disorder are reviewed. A novel approach termed convergent functional genomics, which integrates gene profiling and positional cloning in order to rapidly identify candidate disease genes, is also described.
KW - Bipolar disorder
KW - Functional genomics
KW - Gene expression profiling
KW - Mania
KW - Manic-depressive illness
KW - Microarrays
KW - Psychosis
UR - http://www.scopus.com/inward/record.url?scp=0034981514&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0034981514&partnerID=8YFLogxK
M3 - Article
C2 - 11405548
AN - SCOPUS:0034981514
VL - 33
SP - 263
EP - 271
JO - Annals of Medicine
JF - Annals of Medicine
SN - 0785-3890
IS - 4
ER -