Convergent functional genomics of stem cell-derived cells.

Research output: Contribution to journalArticle

Abstract

Stem cell technologies provide an exciting avenue to directly access the transcriptome of patients in neuronal-like cell types, which might have more direct relevance to brain research than other peripheral tissues (blood, fibroblasts). Enthusiasm should be tempered by concerns that artifacts and noise might be generated as part of the in vitro process of creating and maintaining these cell type. A solution may be to apply a Convergent Functional Genomics approach, where the data from stem cell-derived neuronal cells are integrated, cross-validated and prioritized using independent lines of evidence from other approaches and platforms (human genetic data, human postmortem brain data, animal model data). I provide a brief overview and an example in support of such an approach.

Original languageEnglish
JournalTranslational Psychiatry
Volume3
StatePublished - 2013

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Genomics
Stem Cells
Medical Genetics
Brain
Transcriptome
Artifacts
Noise
Animal Models
Fibroblasts
Technology
Research

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry
  • Cellular and Molecular Neuroscience

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Convergent functional genomics of stem cell-derived cells. / Niculescu, Alexander.

In: Translational Psychiatry, Vol. 3, 2013.

Research output: Contribution to journalArticle

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