Convergent integration of animal model and human studies of bipolar disorder (manic-depressive illness)

Research output: Contribution to journalReview article

11 Citations (Scopus)

Abstract

Animal models and human studies of bipolar disorder and other psychiatric disorders are becoming increasingly integrated, prompted by recent successes. Particularly for genomics, the convergence and integration of data across species, experimental modalities and technical platforms is providing a fit-to-disease way of extracting reproducible and biologically important signal, in sharp contrast to the fit-to-cohort effect, disappointing findings to date, and limited reproducibility of human genetic analyses alone. Such work in psychiatry can provide an example of how to address other genetically complex disorders, and in turn will benefit by incorporating concepts from other areas, such as cancer biology and diabetes.

Original languageEnglish (US)
Pages (from-to)594-600
Number of pages7
JournalCurrent Opinion in Pharmacology
Volume10
Issue number5
DOIs
StatePublished - Oct 1 2010

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Bipolar Disorder
Psychiatry
Animal Models
Cohort Effect
Medical Genetics
Genomics
Neoplasms
Major Affective Disorder 2

ASJC Scopus subject areas

  • Pharmacology
  • Drug Discovery

Cite this

Convergent integration of animal model and human studies of bipolar disorder (manic-depressive illness). / Le-Niculescu, Helen; Patel, Sagar D.; Niculescu, Alexander B.

In: Current Opinion in Pharmacology, Vol. 10, No. 5, 01.10.2010, p. 594-600.

Research output: Contribution to journalReview article

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