Coordinate expression of insulin-like growth factor system components by neurons and neuroglia during retinal and cerebellar development

W. H. Lee, S. Javedan, C. A. Bondy

Research output: Contribution to journalArticle

140 Citations (Scopus)

Abstract

The interactions of insulin-like growth factors (IGFs) with the type I IGF receptor are modulated by a family of high-affinity IGF binding proteins (IGFBPs). One of these, IGFBP2, demonstrates a striking spatiotemporal relationship with IGF-I during cerebellar and retinal development. IGF-I mRNA is transiently expressed in large projection neurons-cerebellar Purkinje and retinal ganglion cells-while IGFBP2 mRNA is selectively expressed by contiguous neuroglia-Bergmann glia in the cerebellum and Muller cells and astrocytes of the nerve fiber layer in the retina. IGF-I and IGFBP2 gene expression is not only neuroanatomically coordinated but also temporally synchronized, peaking together during the postnatal maturation of these structures. This pattern of IGF system expression suggests that IGFBP2 is closely related to IGF-I's action in the developing nervous system.

Original languageEnglish (US)
Pages (from-to)4737-4744
Number of pages8
JournalJournal of Neuroscience
Volume12
Issue number12
StatePublished - 1992
Externally publishedYes

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Somatomedins
Insulin-Like Growth Factor I
Neuroglia
Neurons
Ependymoglial Cells
Somatomedin Receptors
Insulin-Like Growth Factor Binding Proteins
Messenger RNA
Retinal Ganglion Cells
Purkinje Cells
Nerve Fibers
Astrocytes
Cerebellum
Nervous System
Retina
Gene Expression

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Coordinate expression of insulin-like growth factor system components by neurons and neuroglia during retinal and cerebellar development. / Lee, W. H.; Javedan, S.; Bondy, C. A.

In: Journal of Neuroscience, Vol. 12, No. 12, 1992, p. 4737-4744.

Research output: Contribution to journalArticle

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