Coordination of autophagy and the proteasome in resolving endoplasmic reticulum stress

X. Chen, Xiao-Ming Yin

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Macroautophagy is a cellular degradation mechanism that involves the delivery of cytosolic components (macromolecules or organelles) by the autophagosome to the lysosome for degradation. In mammalian cells, macroautophagy and the ubiquitin proteasome system are 2 major mechanisms to eliminate abnormal proteins accumulated in pathological conditions. Here, the coordination of the 2 pathways to alleviate endoplasmic reticulum stress is reviewed. Also discussed is the regulatory role of macroautophagy and proteasome activity in cell survival and death, as well as the recent discoveries leading to novel strategies of simultaneous control of the proteasome and autophagy activity in anticancer treatment.

Original languageEnglish
Pages (from-to)245-253
Number of pages9
JournalVeterinary Pathology
Volume48
Issue number1
DOIs
StatePublished - Jan 2011

Fingerprint

Endoplasmic Reticulum Stress
autophagy
Autophagy
proteasome endopeptidase complex
Proteasome Endopeptidase Complex
endoplasmic reticulum
degradation
lysosomes
ubiquitin
cell viability
organelles
cell death
Ubiquitin
Lysosomes
Organelles
Cell Survival
Cell Death
proteins
cells
Proteins

Keywords

  • anticancer
  • apoptosis
  • autophagy
  • endoplasmic reticulum stress
  • proteasome

ASJC Scopus subject areas

  • veterinary(all)

Cite this

Coordination of autophagy and the proteasome in resolving endoplasmic reticulum stress. / Chen, X.; Yin, Xiao-Ming.

In: Veterinary Pathology, Vol. 48, No. 1, 01.2011, p. 245-253.

Research output: Contribution to journalArticle

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