Copper-62-labeled pyruvaldehyde bis(N4-methylthiosemicarbazonato)copper(II): Synthesis and evaluation as a positron emission tomography tracer for cerebral and myocardial perfusion

M. A. Green, C. J. Mathias, M. J. Welch, A. H. McGuire, D. Perry, F. Fernandez-Rubio, J. S. Perlmutter, M. E. Raichle, S. R. Bergmann

Research output: Contribution to journalArticle

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Abstract

Generator produced positron-emitting radionuclides could potentially expand the application of positron emission tomography (PET) to centers that do not have access to a local cyclotron. The zinc-62/copper-62 radionuclide generator system could serve as a source of positron-emitting copper-62 (62Cu) (t( 1/2 ) = 9.74 min) for physiologic imaging. Accordingly, we have prepared zinc-62/copper-62 generators capable of high output (>300 mCi) and used the no-carrier-added eluate in a rapid high yield synthesis of [62Cu] Cu(PTSM) that provides the radiopharmaceutical in a form suitable for intravenous injection (where Cu(PTSM) = pyruvaldehyde bis(N4-methylthiosemicarbazonato) copper (II)). We then demonstrated in pilot studies that [62Cu]Cu(PTSM) provides high quality brain and heart images with PET, accurately delineating cerebral and myocardial perfusion in both experimental animals and in humans (corroborating results of previous experimental studies utilizing longer-lived copper isotopes). The results of this work demonstrate that 62Cu can be conveniently obtained from high-level generators and, when used to label Cu(PTSM), provides a generator-produced radiopharmaceutical capable of providing estimates of cerebral and myocardial perfusion independent of cyclotron-produced radionuclides.

Original languageEnglish (US)
Pages (from-to)1989-1996
Number of pages8
JournalJournal of Nuclear Medicine
Volume31
Issue number12
StatePublished - Dec 1 1990

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Pyruvaldehyde
Positron-Emission Tomography
Copper
Perfusion
Cyclotrons
Radiopharmaceuticals
Radioisotopes
Radionuclide Generators
Zinc
Electrons
Intravenous Injections
Isotopes
copper pyruvaldehyde bis(N(4)-methylthiosemicarbazone) complex
Brain

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this

Copper-62-labeled pyruvaldehyde bis(N4-methylthiosemicarbazonato)copper(II) : Synthesis and evaluation as a positron emission tomography tracer for cerebral and myocardial perfusion. / Green, M. A.; Mathias, C. J.; Welch, M. J.; McGuire, A. H.; Perry, D.; Fernandez-Rubio, F.; Perlmutter, J. S.; Raichle, M. E.; Bergmann, S. R.

In: Journal of Nuclear Medicine, Vol. 31, No. 12, 01.12.1990, p. 1989-1996.

Research output: Contribution to journalArticle

Green, MA, Mathias, CJ, Welch, MJ, McGuire, AH, Perry, D, Fernandez-Rubio, F, Perlmutter, JS, Raichle, ME & Bergmann, SR 1990, 'Copper-62-labeled pyruvaldehyde bis(N4-methylthiosemicarbazonato)copper(II): Synthesis and evaluation as a positron emission tomography tracer for cerebral and myocardial perfusion', Journal of Nuclear Medicine, vol. 31, no. 12, pp. 1989-1996.
Green, M. A. ; Mathias, C. J. ; Welch, M. J. ; McGuire, A. H. ; Perry, D. ; Fernandez-Rubio, F. ; Perlmutter, J. S. ; Raichle, M. E. ; Bergmann, S. R. / Copper-62-labeled pyruvaldehyde bis(N4-methylthiosemicarbazonato)copper(II) : Synthesis and evaluation as a positron emission tomography tracer for cerebral and myocardial perfusion. In: Journal of Nuclear Medicine. 1990 ; Vol. 31, No. 12. pp. 1989-1996.
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